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2'-Deoxy-2'-fluorocytidine

2'-Deoxy-2'-fluorocytidine structure

CAS No.: 10212-20-1

Chemical Name:: 2'-Deoxy-2'-fluorocytidine

Synonyms: 2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-FLUORO-D-CYTIDINE;2'-Fluoro-d-Cytidine;2'-F-2'-deoxyCytidine

CBNumber:: CB8670324

Molecular Formula:: C9H12FN3O4

Molecular Weight:: 245.21

MDL Number:: MFCD00057445

MOL File:: 10212-20-1.mol

Last updated:2024-11-11 16:49:21

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2'-Deoxy-2'-fluorocytidine Properties

Melting point	167 °C
Boiling point	500.1±60.0 °C(Predicted)
Density	1.82±0.1 g/cm3(Predicted)
refractive index	80 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble in DMSO, Methanol.
pka	12.84±0.70(Predicted)
form	Powder
color	White to Off-white
Water Solubility	Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI	InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey	NVZFZMCNALTPBY-XVFCMESISA-N
SMILES	OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference	10212-20-1(CAS DataBase Reference)
FDA UNII	LCY080JPY9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
HS Code	29389090

2'-Deoxy-2'-fluorocytidine price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D3614	2'-Deoxy-2'-fluorocytidine Hydrate >98.0%(T)	10212-20-1	1g	$68	2024-03-01	Buy
Alfa Aesar	J65632	2'-Fluoro-2'-deoxycytidine, 99%	10212-20-1	1g	$52.65	2024-03-01	Buy
TRC	D232945	2’-Deoxy-2’-fluoroCytidine	10212-20-1	2g	$145	2021-12-16	Buy
TRC	D232945	2’-Deoxy-2’-fluoroCytidine	10212-20-1	10g	$525	2021-12-16	Buy
Medical Isotopes, Inc.	33485	2?-Deoxy-2?-fluorocytidine 98%purewithdatedHPLCUVchromatogram	10212-20-1	1mg	$685	2021-12-16	Buy

Product number	Packaging	Price	Buy
D3614	1g	$68	Buy
J65632	1g	$52.65	Buy
D232945	2g	$145	Buy
D232945	10g	$525	Buy
33485	1mg	$685	Buy

2'-Deoxy-2'-fluorocytidine Chemical Properties,Uses,Production

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

Chemical Properties

White Solid

Uses

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

in vitro

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

References

[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Deoxy-2'-fluorocytidine Suppliers

Global( 314)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemExpress	+86-021-58950125 +86-021-58950125;	info@chemexpress.com	China	737	58
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	info@allbiosyn.com	China	286	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
ChemExpress	58
Allbiosyn Biotechnology Co.,Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 2'-Deoxy-2'-fluorocytidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-08-08	2'-Deoxy-2'-fluorocytidine 10212-20-1	US $0.00 / g	100g	≥98%	20t	Hefei Huana Biomedical Technology Co.,Ltd.
2023-04-04	2'-FLUORO-D-CYTIDINE 10212-20-1	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.
2023-03-22	2'-F-2'-deoxyCytidine；2‘-F-dC 10212-20-1	US $100.00 / kg	0.009999999776482582kg	99%	5tons	SHANGHAI NOVRIBO BIOTECH

2'-Deoxy-2'-fluorocytidine
10212-20-1
US $0.00 / g
≥98%
Hefei Huana Biomedical Technology Co.,Ltd.

2'-FLUORO-D-CYTIDINE
10212-20-1
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-F-2'-deoxyCytidine；2‘-F-dC
10212-20-1
US $100.00 / kg
99%
SHANGHAI NOVRIBO BIOTECH

2'-Deoxy-2'-fluorocytidine Spectrum

4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)¹HNMR 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)IR1 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)IR2

10212-20-1(2'-Deoxy-2'-fluorocytidine)Related Search:

Cytidine 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluorocytidine Dmt-2'-f-dc(ac) amidite

2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Gemcitabine hydrochloride 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2''-DEOXY-2''-FLUORO-5-IODOCYTIDINE 2'-FLUORO-5'-O-DIMETHOXYTRITYL-N4-ACETYL-D-CYTIDINE

2'-DEOXY-3',5'-DI-O-BENZOYL-2',2'-DIFLUOROCYTIDINE-13C,15N2 DTBS-GEMCITABINE gemcitabine 2'-DEOXY-2'-FLUOROCYTIDINE, [3H]- 2'-FLUORO-2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT

GEMCITABINE, [5-3H]- N4-Benzyl-2'-deoxy-2'-fluoro-5'-O-tritylcytidine-3'-O-cyanoethyldiisopropropylphosphoramidite

1of4

4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE 2'-FLUORO-D-CYTIDINE 2'-DEOXY-2'-FLUOROCYTIDINE 2'-FC 2'-FLUORO-2'-DEOXYCYTIDINE 2'-FdC 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine RO-8013 2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC) 2'-Deoxy-2'-fluoro-D-cytidine 2''-DEOXY-2''-FLUOROCYTIDINE,99+% 2'-Deoxy-2'-fluorocytidine Hydrate 2'-Deoxy-2'-fluorocytidine ,98% 2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine FN-009 2'-Fluoro-2'-deoxy-cytidine Cytidine, 2'-deoxy-2'-fluoro- 2'-FANA-C NSC 529432 2'-Deoxy-2'-fluorocytidine 2'-Deoxy-2'-fluorocytidine≥ 99% (HPLC) Fludarabine Phosphate Impurity 18 2'-Fluoro-2'-deoxycytidine, >98.0%(T) 2'-Deoxy-2'-fluorocytidineHydrate> 2’-F-2’-dC 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one USP/EP/BP 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl... 2'-F-2'-deoxyCytidine Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV 2'-Fluoro-2'-Deoxycytidine (FdC) 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 2'-Fluoro-2'-Deoxycytidine 2'-Deoxy-2"-fuorocytidine 2'-F-2'-deoxycytidine 2'-Deoxy-2'-fluorocytidine 2'-F-dC Cytidine, 2'-deoxy-2'-fluoro- 2'-Fluoro-d-Cytidine 10212-20-1 110212-20-1 C9H12FN3O4xH2O C9H12N3O4F C9H12FN3O4 Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents 10212-20-1 Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-F Nucleosides