N-NITROSOPYRROLIDINE

N-NITROSOPYRROLIDINE Properties

Boiling point	214 °C(lit.)
Density	1.085 g/mL at 25 °C(lit.)
refractive index	n20/D 1.489(lit.)
Flash point	182 °F
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate, Methanol (Slightly)
form	Oil
pka	-3.14±0.20(Predicted)
color	Pale Yellow to Yellow
CAS DataBase Reference	930-55-2(CAS DataBase Reference)
EWG's Food Scores	1-3
FDA UNII	SZ4J5WK201
Proposition 65 List	N-Nitrosopyrrolidine
IARC	2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System	N-Nitrosopyrrolidine (930-55-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H302-H351
Precautionary statements	P281
Hazard Codes	Xn
Risk Statements	40
RIDADR	2810
WGK Germany	3
RTECS	UY1575000
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 orally in rats: 900 mg/kg (Druckrey)

N-NITROSOPYRROLIDINE price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	N545950	1-Nitrosopyrrolidine	930-55-2	1g	$55	2021-12-16	Buy
Usbiological	487129	NPY1R	930-55-2	100ul	$529	2021-12-16	Buy
Biorbyt Ltd	orb597102	NPY1R	930-55-2	10μg	$290.7	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0006919	1-NITROSOPYRROLIDINE 95.00%	930-55-2	100MG	$704.55	2021-12-16	Buy
Medical Isotopes, Inc.	12686	1-Nitrosopyrrolidine	930-55-2	100mg	$860	2021-12-16	Buy

Product number	Packaging	Price	Buy
N545950	1g	$55	Buy
487129	100ul	$529	Buy
orb597102	10μg	$290.7	Buy
CHM0006919	100MG	$704.55	Buy
12686	100mg	$860	Buy

N-NITROSOPYRROLIDINE Chemical Properties,Uses,Production

Description

N-Nitrosopyrrolidine (NPYR) is a nitrosamine compound that is used primarily as a research chemical and is not produced commercially. There is the possibility of generating NPYR after frying in dry-cured bacon. The major amine precursors to NPYR in cooked bacon are free proline in the adipose tissue and to a lesser extent, collagenous connective tissues. When proline peptides were heated with nitrite at pH 3.4, small amounts of NPYR were formed from all tested peptides. There are several potential sources of exposure of man to this group of potent carcinogens. Certain foods were thought to be derived from the interaction of nitrite with secondary amines in the food, either spontaneously or by the agency of bacteria. Recently the possibility that nitrosamines may be formed from secondary amines and nitrite in the gastrointestinal tract has been explored. The acid conditions that prevail in the human stomach favor the nitrosation of dimethylamine. In addition, at neutral pH, many secondary amines can be nitrosated by nitrite or nitrate in the presence of intestinal bacteria, or the cecal contents of the rat, and soluble enzymes which catalyze the N-nitrosation of several secondary amines have been extracted from two microorganisms. The rate of nitrosamine formation depends greatly on the basicity of the amine; the less basic amines such as diphenylamine and pyrrolidine are nitrosated far more readily than the strongly basic dimethylamine and diethylamine.

Chemical Properties

Light-Yellow Oil

Chemical Properties

N-Nitrosopyrrolidine is a yellow liquid.

Uses

One of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated.

Uses

1-Nitrosopyrrolidine is one of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis (1,2,3) but the toxicological mechanisms involved have not been elucidated. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Definition

ChEBI: N-Nitrosopyrrolidine is a member of pyrrolidines.

General Description

Yellow liquid found in certain food products and tobacco smoke. Probably a carcinogen.

Air & Water Reactions

Soluble in water.

Reactivity Profile

A cyclic nitrosamine. Nitrated organics, such as N-NITROSOPYRROLIDINE, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.

Health Hazard

ACUTE/CHRONIC HAZARDS: Flammable.

Fire Hazard

Combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Potential Exposure

N-Nitrosopyrrolidine is a cyclic nitrosamine and a research chemical. Not commercially produced in the U.S.

Carcinogenicity

N-Nitrosopyrrolidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

It is a yellow liquid at room temperature. It is totally soluble in water with solubility of 1.00×10+6 mg l^-1 and also is soluble in organic liquids and lipids. Log Pow is -0.19 that expected to move readily from water to soil, sediment, or biota. According to Henry’s law constant 4.89×10^-8 atmm³ mol^-1 and vapor pressure 0.06 mmHg in 20 ℃, volatilization from water and solid surface is expected to be rapid and an important fate process.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Toxicity evaluation

2-OHTHF and several other reactive electrophilic intermediates can bind with proteins and form DNA adducts mainly with guanines.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

N-NITROSOPYRROLIDINE synthesis

Synthesis of N-NITROSOPYRROLIDINE from Pyrrolidine

N-NITROSOPYRROLIDINE Preparation Products And Raw materials

Raw materials

Pyrrolidine-1-d Pyrrolidine, 1-fluoro- N-[10-(13,14-Methylenedioxyphenyl)-7(E),9(Z)-pentadienoyl]-pyrrolidine 1-Nitropyrrolidine 1-Acetylpyrrolidine

N-nitrosomethyl-(2-hydroxyethyl)amine N-PROPYL NITRITE N-Methyl-p-toluenesulfonamide Bromonitromethane

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Preparation Products

1-FORMYLPYRROLIDINE 1-AMINOPYRROLIDINE Pyrrolidine

N-NITROSOPYRROLIDINE Suppliers

Global( 122)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
Chemsigma International Co., Ltd.	+86-18136843612 +86-19951791336	info@chemsigma.com	China	1363	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32343	55

Supplier	Advantage
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Chemsigma International Co., Ltd.	58
sgtlifesciences pvt ltd	58
Alfa Chemistry	58
LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Mainchem Co., Ltd.	55

N-NITROSOPYRROLIDINE Spectrum

N-NITROSOPYRROLIDINE(930-55-2)MS N-NITROSOPYRROLIDINE(930-55-2)¹HNMR N-NITROSOPYRROLIDINE(930-55-2)¹³CNMR N-NITROSOPYRROLIDINE(930-55-2)IR1

930-55-2(N-NITROSOPYRROLIDINE)Related Search:

N'-NITROSONORNICOTINE N-NITROSOPYRROLIDINE DL-N'-NITROSONORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) N'-Nitrosonornicotine-N-b-D-glucuronide N-METHYL-N'-NITROSONORNICOTINIUM IODIDE

rac N'-Nitrosonornicotine 2,5-DIMETHYL-N-NITROSOPYRROLIDINE,2,5-Dimethyl-1-nitrosopyrrolidine N-NITROSOPYRROLIDINE-D8 2-Pyrrolidinone,1-nitro- N-NITROSO-L-PROLINE

N-NITROSO-D-PROLINE rac-N'-Nitrosonornicotine 1-N-Oxide 2-HYDROXY-1-NITROSOPYRROLIDINE alpha-acetoxy-N-nitrosopyrrolidine 6,7-DIMETHYL-4-NITRO-4-AZATRICYCLO[4.3.0.0(3,7)]NONANE-3-CARBONITRILE

3A,6A-DIMETHYL-2-NITROHEXAHYDRO-1,4-METHANOCYCLOPENTA[C]PYRROLE-1(2H)-CARBOXAMIDE 3-Pyrrolidinone,1-nitro- (R)-N-NITROSONORNICOTINE, [PYRIDYL-5-3H]-

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1-nitroso-pyrrolidin 1-Pyrrolidinamine, N-nitroso- Nitrosopyrrolidine N-NITROSOPYRROLIDINE ISOPAC Pyrrolidine, 1-nitroso- N-Nitrosopyrolidine 1-Nitrosopyrrolidine,N-Nitrosopyrrolidine, NPYR NSC 18797 Neuropeptide Y receptor type 1 NPY1R NPY1-R NPYY1 n-nitroso-1-pyrrolidinamin N-Nitrosopyrrolidin n-nitrosopyrrolidin[german] n-n-pyr No-Pyr NPYR n-pyr rcrawastenumberu180 tetrahydro-n-nitroso-pyrrol N-NITROSOPYRROLIDINE 1-NITROSOPYRROLIDINE 1-Nitrosopyrrolidine（NPYR） N-Nitrosopyrrolidine@5.0 mg/mL in MeOH N-nitrosopyrrolidineSolution,100mg/L,1ml N-Nitrosopyrrolidine@100 μg/mL in Dichloromethane N-nitropyrrolidine N-nitroso-pyrrolidine NPYR3,7 N-Nitrosopyrrolidine in dichloromethane 930-55-2 Carcinogens Cancer Research BioChemical Mutagenesis Research Chemicals Nitrosamine Nitric Oxide Reagents