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PROTAC IRAK4 degrader-1

PROTAC IRAK4 degrader-1 Structure
PROTAC IRAK4 degrader-1 structure
CAS No.
2360533-90-8
Chemical Name:
PROTAC IRAK4 degrader-1
Synonyms
PROTAC IRAK4 degrader-1;2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide
CBNumber:
CB88054605
Molecular Formula:
C44H39F3N12O7
Molecular Weight:
904.85
MDL Number:
MFCD34469671
MOL File:
Mol file
Last updated:2024-07-02 08:55:37
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PROTAC IRAK4 degrader-1 Properties

Density 1.61±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 10.74±0.40(Predicted)
form Solid
color White to yellow

PROTAC IRAK4 degrader-1 Chemical Properties,Uses,Production

Biological Activity

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

PROTAC IRAK4 degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC IRAK4 degrader-1 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9943 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1382 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 13417589054 trendseenbio@gmail.com China 9880 58
Elucigen bio 13501719342 wayne.zheng@elucigenbio.com China 4587 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Chaolan Chemical Technology Center 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Elucigen bio 58

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PROTAC IRAK4 degrader-1 2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide 2360533-90-8