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PROTAC K-Ras Degrader-1

PROTAC K-Ras Degrader-1 Structure
PROTAC K-Ras Degrader-1 structure
CAS No.
2378258-52-5
Chemical Name:
PROTAC K-Ras Degrader-1
Synonyms
K-Ras Degrader-1;PROTAC K-Ras Degrader-1;2-Piperazineacetonitrile, 4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-
CBNumber:
CB15540584
Molecular Formula:
C53H62N10O10
Molecular Weight:
999.14
MDL Number:
MFCD32263411
MOL File:
2378258-52-5.mol
Last updated:2024-07-02 08:55:01
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PROTAC K-Ras Degrader-1 Properties

Density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 33.33 mg/mL (33.36 mM)
pka 10.74±0.40(Predicted)
form Solid
color Light yellow to yellow

PROTAC K-Ras Degrader-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0106329 PROTACK-RasDegrader-1 98.05% 2378258-52-5 1mg $550 2021-12-16 Buy
ChemScene CS-0106329 PROTACK-RasDegrader-1 98.05% 2378258-52-5 5mg $1500 2021-12-16 Buy
ChemScene CS-0106329 PROTACK-RasDegrader-1 98.05% 2378258-52-5 10mg $2500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0106329 1mg $550 Buy
CS-0106329 5mg $1500 Buy
CS-0106329 10mg $2500 Buy

PROTAC K-Ras Degrader-1 Chemical Properties,Uses,Production

Description

PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].

References

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

PROTAC K-Ras Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC K-Ras Degrader-1 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1461 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 13417589054 trendseenbio@gmail.com China 9470 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4988 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Province Woda Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
cjbscvictory 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58

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PROTAC K-Ras Degrader-1 K-Ras Degrader-1 2-Piperazineacetonitrile, 4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- 2378258-52-5