Coenzyme A
- CAS No.
- 85-61-0
- Chemical Name:
- Coenzyme A
- Synonyms
- COA;COA-SH;COENZYME A HYDRATE;Lucina;Coalip;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
- CBNumber:
- CB8854470
- Molecular Formula:
- C21H36N7O16P3S
- Molecular Weight:
- 767.53
- MDL Number:
- MFCD06795839
- MOL File:
- 85-61-0.mol
- MSDS File:
- SDS
| Density | 1.96±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+) |
| color | White to light yellow |
| Merck | 13,2491 |
| BRN | 77809 |
| InChIKey | RGJOEKWQDUBAIZ-IBOSZNHHSA-N |
| SMILES | SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O |
| LogP | -4.358 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | SAA04E81UX |
| EPA Substance Registry System | Coenzyme A (85-61-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933299090 | |||||||||
| NFPA 704 |
|
Coenzyme A price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C4282 | Coenzyme A hydrate ≥85% (UV, HPLC) | 85-61-0 | 10mg | $81.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | C4282 | Coenzyme A hydrate ≥85% (UV, HPLC) | 85-61-0 | 25mg | $135 | 2024-03-01 | Buy |
| Alfa Aesar | J13787 | Coenzyme A trihydrate, free acid, Affymetrix/USB | 85-61-0 | 50mg | $108.19 | 2021-12-16 | Buy |
| Alfa Aesar | J13787 | Coenzyme A trihydrate, free acid, Affymetrix/USB | 85-61-0 | 1g | $1350.25 | 2021-12-16 | Buy |
| Cayman Chemical | 16147 | Coenzyme A ≥98% | 85-61-0 | 10mg | $74 | 2024-03-01 | Buy |
Coenzyme A Chemical Properties,Uses,Production
Description
Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-
Chemical Properties
yellowish lyophilisate
Uses
Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.
Uses
A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.
Definition
ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).
General Description
Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.
Biochem/physiol Actions
Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.
Purification Methods
The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]
Coenzyme A Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Oxsyns Biotech | +86-86-18382622232 +8618382622232 | yilin.fan@oxsyns.com | China | 9 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 390 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17453 | 58 |
View Lastest Price from Coenzyme A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Coenzyme A
85-61-0
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-11-28 | Coenzyme A
85-61-0
|
US $85.00-25.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-19 | Coenzyme A
85-61-0
|
US $36.00-76.00 / mg | 93.84% | 10g | TargetMol Chemicals Inc. |
-
- Coenzyme A
85-61-0
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD
-
- Coenzyme A
85-61-0
- US $85.00-25.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Coenzyme A
85-61-0
- US $36.00-76.00 / mg
- 93.84%
- TargetMol Chemicals Inc.