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Sevelamer

CAS No.
52757-95-6
Chemical Name:
Sevelamer
Synonyms
Hsdb 7608;Sevelamer;Sevelamer [inn:ban];Epichlorohydrin-PAA 25 copolymer;Allylamine-epichlorohydrin copolymer;Allylamine polymer with 1-chloro-2,3-epoxypropane;2-Propen-1-amine, polymer with (chloromethyl)oxirane;Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine
CBNumber:
CB91106827
Molecular Formula:
C6H12ClNO
Molecular Weight:
149.62
MDL Number:
MFCD09260188
MOL File:
52757-95-6.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17

Sevelamer Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
FDA UNII 941N5DUU5C
ATC code V03AE02

SAFETY

Risk and Safety Statements

Hazardous Substances Data 52757-95-6(Hazardous Substances Data)

Sevelamer price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals DC10310 Sevelamer >98% 52757-95-6 100mg $100 2021-12-16 Buy
DC Chemicals DC10310 Sevelamer >98% 52757-95-6 1g $400 2021-12-16 Buy
Product number Packaging Price Buy
DC10310 100mg $100 Buy
DC10310 1g $400 Buy

Sevelamer Chemical Properties,Uses,Production

Uses

Antihyper-phosphatemic.

brand name

Renagel (Genzyme).

Pharmaceutical Applications

In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces.

Clinical Use

Phosphate-binding agent

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration.

Metabolism

Sevelamer is not systemically absorbed.

Sevelamer Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Wuhan Golt Biotech Co., Ltd.
+8615389281203 maria@goltbiotech.com China 970 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49978 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Gihi Chemicals Co., Limited +86-0571-86217390 +8618058761490 info@gihichem.com China 998 58
Cantotech Chemicals, Ltd. 86-0755-86635001 cantotech@126.com China 4566 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58
Musechem +1-800-259-7612 info@musechem.com United States 4660 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Sevelamer 2-Propen-1-amine, polymer with (chloromethyl)oxirane Allylamine polymer with 1-chloro-2,3-epoxypropane Allylamine-epichlorohydrin copolymer Hsdb 7608 Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine Sevelamer [inn:ban] Epichlorohydrin-PAA 25 copolymer 52757-95-6 C3H7NxC3H5ClOx