Sevelamer
- CAS No.
- 52757-95-6
- Chemical Name:
- Sevelamer
- Synonyms
- Hsdb 7608;Sevelamer;Sevelamer [inn:ban];Epichlorohydrin-PAA 25 copolymer;Allylamine-epichlorohydrin copolymer;Allylamine polymer with 1-chloro-2,3-epoxypropane;2-Propen-1-amine, polymer with (chloromethyl)oxirane;Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine
- CBNumber:
- CB91106827
- Molecular Formula:
- C6H12ClNO
- Molecular Weight:
- 149.62
- MDL Number:
- MFCD09260188
- MOL File:
- 52757-95-6.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| FDA UNII | 941N5DUU5C |
| ATC code | V03AE02 |
Sevelamer Chemical Properties,Uses,Production
Uses
Antihyper-phosphatemic.
brand name
Renagel (Genzyme).
Pharmaceutical Applications
In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces.
Clinical Use
Phosphate-binding agent
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of
ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration.
Metabolism
Sevelamer is not systemically absorbed.
Sevelamer Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15354 | 58 |
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 | maria@goltbiotech.com | China | 970 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Gihi Chemicals Co., Limited | +86-0571-86217390 +8618058761490 | info@gihichem.com | China | 998 | 58 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4566 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |