Nisoxetine
- CAS No.
- 53179-07-0
- Chemical Name:
- Nisoxetine
- Synonyms
- Nisoxetine;Compound 89218;Benzenepropanamine, γ-(2-methoxyphenoxy)-N-methyl-;[3-(2-Methoxy-phenoxy)-3-phenyl-propyl]-methyl-amine
- CBNumber:
- CB91179324
- Molecular Formula:
- C17H21NO2
- Molecular Weight:
- 271.36
- MDL Number:
- MFCD00865443
- MOL File:
- 53179-07-0.mol
| Boiling point | 404.8±40.0 °C(Predicted) |
|---|---|
| Density | 1.054±0.06 g/cm3(Predicted) |
| pka | 10.16±0.10(Predicted) |
| form | Viscous Liquid |
| color | Colorless to light yellow |
| FDA UNII | 17NV064B2D |
Nisoxetine Chemical Properties,Uses,Production
Uses
Antidepressant.
Definition
ChEBI: Nisoxetine is a secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group. It has a role as an antidepressant and an adrenergic uptake inhibitor. It is an aromatic ether and a secondary amino compound.
General Description
Nisoxetine is a SNERI and is an antidepressant. Most activityresides in the β-isomer.
Clinical Use
Nisoxetine was the initial phenoxyphenylpropylamine synthesized in the Lilly research laboratories during the early 1970s from the rearrangement of an oxygen atom in diphenyhydramine, a diphenylmethoxyethylamine, to a phenoxyphenylpropylamine. Nisoxetine was discovered to be a potent and very selective SNRI, with little affinity for other receptors. It underwent clinical studies as an alternative to Lilly's best-selling antidepressant, nortriptyline, but without the adverse effects associated with the tricyclic secondary amines. It was never marketed, however, because of a greater interest in developing its 4-trifluoromethyl analogue, fluoxetine, an SSRI.
Nisoxetine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9887 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-88590548 18341751992 | 757984502@qq.com | China | 892 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
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