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Iron-dextran

CAS No.
9004-66-4
Chemical Name:
Iron-dextran
Synonyms
IRON DEXTRAN;Iron dextran solution;INFeD;DexferruM;b75;a100;Dextran iron;Dexfer;Idofer;fenate
CBNumber:
CB9139534
Molecular Formula:
FeH2O4S
Molecular Weight:
153.92348
MDL Number:
MFCD00081553
MOL File:
9004-66-4.mol
Last updated:2024-12-18 14:15:32

Iron-dextran Properties

storage temp. Room Temperature
solubility Water (Slightly)
form solution
color Very Dark Red to Black
Water Solubility Iron, ~100?mg/mL in water
EWG's Food Scores 1
FDA UNII 95HR524N2M
NCI Drug Dictionary iron dextran complex
Proposition 65 List Iron Dextran Complex
IARC 2B (Vol. 2, Sup 7) 1987
EPA Substance Registry System Iron dextran (9004-66-4)

Pharmacokinetic data

Excreted unchanged in urine <0.2%
Volume of distribution 0.031-0.055(L/kg)
Biological half-life 5-20 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H317-H350
Precautionary statements  P202-P261-P272-P280-P302+P352-P308+P313
Hazard Codes  Xn,T
Risk Statements  40-42/43-43-45
Safety Statements  23-26-36/37/39-45-36-36/37-53
WGK Germany  -
RTECS  NI2200000
Hazardous Substances Data 9004-66-4(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 2240 mg Fe/kg (Beliles)

Iron-dextran price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D8517 Iron–Dextran solution 9004-66-4 25ml $173 2024-03-01 Buy
Sigma-Aldrich D8517 Iron–Dextran solution 9004-66-4 100ml $446 2024-03-01 Buy
TRC I774950 IronDextran 9004-66-4 100g $1190 2021-12-16 Buy
Usbiological 280362 Iron dextran 9004-66-4 5g $337 2021-12-16 Buy
Usbiological 014961 Iron Dextran 9004-66-4 10g $425 2021-12-16 Buy
Product number Packaging Price Buy
D8517 25ml $173 Buy
D8517 100ml $446 Buy
I774950 100g $1190 Buy
280362 5g $337 Buy
014961 10g $425 Buy

Iron-dextran Chemical Properties,Uses,Production

Description

Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)
Iron-Dextran is for the parenteral treatment of iron-deficiency anemia in humans and baby pigs. Can be used as a reagent.

Chemical Properties

Light to dark brown powder. Colloidal suspension of an iron-dextran complex in water. pH 5.2-6.5.

History

The therapeutic value of colloidal iron preparations was first reported in the 1950's by London and Twigg. Numerous attempts have been made to improve these iron preparations Thus dextran ([h] 0.05) is first heated with alkali, and is then neutralized in the presence of ferric chloride solution. Studies on this product have revealed that each particle consists of a central iron core, approximately 3nm diameter, surrounded by a dextran sheath of approximately 13nm diameter. The complex is visualized as a particle formed by a protective sheath of dextran attached by terminal metasaccharinic acid units to a b-FeOOH core. A solution of this complex containing 5% iron and 20% dextran (Imferon ™ ) is suitable for intramuscular and intravenous injection for treating iron deficiency anemia. The product is currently used widely for treating anemia in new-born piglets.
The use of these preparations has been re-examined in humans and a dramatic rise in hemoglobin was reported following intravenous infusion. The solution is best administered together with glucose solutions.

Uses

Hematinic.

Uses

Iron-Dextran (ferric hydroxide dextran complex) may be used as an intravenous iron delivery preparation. Iron-Dextran may be used to induce iron-overload to study its effects and preventative measures.

brand name

Dexferrum (Luitpold); Infed (Wat son); Proferdex (New River).

Reactivity Profile

Iron-dextran is unstable at a pH of 5 and decomposes at 149-158° F. Iron-dextran may be sensitive to prolonged exposure to air.

Health Hazard

SYMPTOMS: The symptoms associated with exposure to Iron-dextran are headaches, vomiting, and dizziness.

Fire Hazard

Iron-dextran is combustible.

Clinical Use

Prophylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated)

Treatment of iron deficiency during ESA therapy especially if serum ferritin is very low (<50 nanograms/mL)

Drug interactions

Potentially hazardous interactions with other drugs
Dimercaprol: avoid concomitant use.
Oral iron: reduced absorption of oral iron

Carcinogenicity

Iron dextran complex is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Metabolism

After intravenous infusion, iron dextran is taken up by the cells of the reticuloendothelial cells, particularly in the liver and spleen. The reticuloendothelial cells gradually separate iron from the iron-dextran complex. Most absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin; the remainder is contained within the storage forms, ferritin or haemosiderin, or as myoglobin, with smaller amounts occurring in haem-containing enzymes or in plasma bound to transferrin.
Only very small amounts of iron are excreted as the majority released after the destruction of the haemoglobin molecule is re-used.

Iron-dextran Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 272)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5857 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 info@fortunachem.com China 5975 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630 bess@weibangbio.com China 18151 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649 sarah@tnjone.com China 1143 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714 FandaChem@Gmail.com China 9084 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763 info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58

Related articles

View Lastest Price from Iron-dextran manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Iron-dextran pictures 2024-12-13 Iron-dextran
9004-66-4
US $0.00 / KG 25KG 20%(200mg Fe/ml);USP 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD
Iron-dextran pictures 2024-11-01 Iron-dextran
9004-66-4
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
Iron-dextran pictures 2024-10-25 Iron-dextran
9004-66-4
US $25.00-10.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
  • Iron-dextran pictures
  • Iron-dextran
    9004-66-4
  • US $0.00 / KG
  • 20%(200mg Fe/ml);USP
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Iron-dextran pictures
  • Iron-dextran
    9004-66-4
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd
  • Iron-dextran pictures
  • Iron-dextran
    9004-66-4
  • US $25.00-10.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
ursoferran Iron Dextran, Fe 28-33% w/w Iron Dextran, Fe 14-18% w/w a100(pharmaceutical) chinofer dextranironcomplex dextrofer75 eisendextran Iron Dextran 10% IRONDEXTRAN(VET) DEXTRANIRON20%OR35% Iron Dextran 20 % POLYSACCHARIDEFERRICCOMPLEX IRONDEXTRAN5%POWDER FERRIC HYDROXIDE DEXTRAN COMPLEX IRON DEXTRAN POWDER CosMoFer Dexfer Dextran Magnetite Dextran-iron Oxide Dextrofer 100 Ferran 100 FerraniMal 75 FerraniMal 75M Ferrodex 100 Ferroglukin Hyferdex Idofer IMpheron Iron-GARD IronorM KeMofei NoneMic Proferedex SHU 555 DEXFERRUM (iron dextran) Iron Dextran, Fe 33-40% w/w fe-dextran fenate ferdex100 ferricdextran ferridextran ferrodextran ferroglucin ferroglukin75 imferon imposil iro-jex iron-dextrancomplex irondextraninjection ironhydrogenateddextran ironorminjection miofer100 myofer100 polyfer prolongal rcrawastenumberu139 Iron–Dextran, Fe 35-40% w/w