ORITAVANCIN
- CAS No.
- 171099-57-3
- Chemical Name:
- ORITAVANCIN
- Synonyms
- CS-2274;Orbactiv;LY 333328;ORITAVANCIN;Ollivan Star;brand name: Orbactiv;Oritavancin (LY333328);Oritavancin, trifluoacetate salt;13C6]-Oritavancin, trifluoacetate salt;Oritavancin (Lyophilized Powder For IV Infusion)
- CBNumber:
- CB92451283
- Molecular Formula:
- C86H97Cl3N10O26
- Molecular Weight:
- 1793.1
- MDL Number:
- MFCD12756396
- MOL File:
- 171099-57-3.mol
- MSDS File:
- SDS
Density | 1.59±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
pka | 2.93±0.70(Predicted) |
FDA UNII | PUG62FRZ2E |
ATC code | J01XA05 |
ORITAVANCIN Chemical Properties,Uses,Production
Definition
ChEBI: A semisynthetic glycopeptide used (as its bisphosphate salt) for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.
Clinical Use
Antibacterial agent
Enzyme inhibitor
This novel, semi-synthetic glycopeptide antibiotic (FW = 1793.10 g/mol; CAS 171099-57-3), also known as LY333328, Orbactiv?, and (4R)-22-O- (3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabinohexopyranosyl)-N3-(p-(pchlorophenyl) benzyl)vancomycin, disrupts the cell membrane of Grampositive bacteria and inhibits both transglycosylation and transpeptidation. Oritavancin differs from vancomycin by the presence of a hydrophobic N-4-(4-chlorophenyl)benzyl substituent on the disaccharide, the addition of a 4-epi-vancosamine monosaccharide to the amino acid residue in Ring-6, and replacement of the vancosamine moiety by 4-epi-vancosamine. When compared vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillinresistant methicillinresistant Staphylococcus aureus, LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Indeed, a single infusion of this antibiotic (1200 mg) can clear serious bacterial skin infections, including methicillin-resistant Staphylococcus aureus, or MRSA, as effectively as the usual 7-10 day, twice-daily regimen of vancomycin now needed to treat patients.
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: possibly increases warfarin
concentration.
Metabolism
In vitro human liver microsome studies indicated that oritavancin is not metabolised. It is excreted unchanged; less than 1% and 5% of a dose is recovered in the urine and the faeces.
ORITAVANCIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3128 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15386 | 58 |
Related articles
- What is Oritavancin?
- Oritavancin is a second-generation lipoglycopeptide antibiotic derived from modifications of chloroeremomycin, a naturally occ....
- Mar 10,2022
View Lastest Price from ORITAVANCIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-12 | ORITAVANCIN
171099-57-3
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
2021-11-23 | ORITAVANCIN
171099-57-3
|
US $12.00 / g | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | ||
2020-11-16 | ORITAVANCIN
171099-57-3
|
US $20.00 / KG | 1KG | 99 | 999 | Longyan Tianhua Biological Technology Co., Ltd |
- ORITAVANCIN
171099-57-3
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
- ORITAVANCIN
171099-57-3
- US $12.00 / g
- 99%
- Qiuxian Baitai New Material Co., LTD
- ORITAVANCIN
171099-57-3
- US $20.00 / KG
- 99
- Longyan Tianhua Biological Technology Co., Ltd