Bafetinib
- CAS No.
- 859212-16-1
- Chemical Name:
- Bafetinib
- Synonyms
- Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;NS-187|||INNO-406;Bafetinib (INNO-406)
- CBNumber:
- CB92473854
- Molecular Formula:
- C30H31F3N8O
- Molecular Weight:
- 576.62
- MDL Number:
- MFCD18633200
- MOL File:
- 859212-16-1.mol
- MSDS File:
- SDS
Melting point | 166-168°C |
---|---|
Density | 1.36±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM) |
form | A crystalline solid |
pka | 12.72±0.70(Predicted) |
color | Light yellow to yellow |
FDA UNII | NVW4Z03I9B |
Bafetinib price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 5mg | $118 | 2024-03-01 | Buy |
Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 10mg | $214 | 2024-03-01 | Buy |
TRC | B109050 | Bafetinib | 859212-16-1 | 5mg | $90 | 2021-12-16 | Buy |
Biorbyt Ltd | orb180774 | Bafetinib (INNO-406) >98% | 859212-16-1 | 1g | $2172.6 | 2021-12-16 | Buy |
Bafetinib Chemical Properties,Uses,Production
Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.
Chemical Properties
Pale Yellow Solid
Uses
A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.
Bafetinib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 990 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
View Lastest Price from Bafetinib manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-07-07 | Bafetinib USP/EP/BP
859212-16-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
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2019-07-06 | Bafetinib
859212-16-1
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- Bafetinib USP/EP/BP
859212-16-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Bafetinib
859212-16-1
- US $1.00 / kg
- 98%
- Career Henan Chemical Co