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GSK1904529A

GSK1904529A Structure
GSK1904529A structure
CAS No.
1089283-49-7
Chemical Name:
GSK1904529A
Synonyms
CS-29;GSK 4529;GSK1904529A;GSK1904529A, >=98%;GSK1904529A (GSK-4529;IGF-IR, IGF-IIR inhibitor;IGF-1R inhibitor GS1904529A;GSK1904529A ISO 9001：2015 REACH;GSK1904529A;GSK-1904529A;GSK 1904529A;GSK1904529A : IGF-IR, IGF-IIR inhibitor
CBNumber:
CB92501005
Molecular Formula:
C44H47F2N9O5S
Molecular Weight:
851.96
MDL Number:
MFCD17010271
MOL File:
1089283-49-7.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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GSK1904529A Properties

Density 1.39
storage temp. Store at -20°C
solubility ≥42.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 11.12±0.70(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

GSK1904529A price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29155 GSK1904529A 1089283-49-7 5mg $116 2024-03-01 Buy
Cayman Chemical 29155 GSK1904529A 1089283-49-7 25mg $456 2024-03-01 Buy
Cayman Chemical 29155 GSK1904529A 1089283-49-7 1mg $32 2024-03-01 Buy
Cayman Chemical 29155 GSK1904529A 1089283-49-7 10mg $214 2024-03-01 Buy
TRC G797490 GSK1904529A 1089283-49-7 5mg $170 2021-12-16 Buy
Product number Packaging Price Buy
29155 5mg $116 Buy
29155 25mg $456 Buy
29155 1mg $32 Buy
29155 10mg $214 Buy
G797490 5mg $170 Buy

GSK1904529A Chemical Properties,Uses,Production

Uses

GSK 1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.

Uses

A selective inhibitor of IGF-1R and IR with IC50s of 27 nM and 25 nM, respectively.

Definition

ChEBI: N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide is a member of benzamides.

Biological Activity

gsk1904529a is a small-molecule inhibitor of the insulin-like growth factor-i receptor (igf-ir) with ic50 value of 27 nm 1.gsk1904529a is a reversible and atp-competitive inhibitor with ki value of 1.6 nm. in nih-3t3/lisn cells, gsk1904529a potently inhibited phosphorylation of igf-ir with ic50 value of 22 nm. it also demonstrated to be a selective inhibitor since it showed poor inhibitory activity against 45 other serine/threonine and tyrosine kinases. when treated with whole-cell extracts, gsk1904529a significantly inhibited the ligand-induced phosphorylation of igf-ir and decreased phosphorylation of downstream signaling including akt, irs-1 and erk at concentrations > 0.01μm. gsk1904529a suppressed cell proliferation in a variety of tumor cells. the ic50 values for nci-h929, tc-71, sk-n-mc, colo 205, mcf7 and prec are 81, 35, 43, 124, 137 and 68 nm, respectively. in colo 205, mcf-7, and nci-h929 cells, gsk1904529a treatment resulted in cell accumulation in g1 and decrease in s and g2-m phases. moreover, in nih-3t3/lisn xenograft model, once daily administration of gsk1904529a at 30 mg/kg inhibited 56% of tumor growth 1.

target

IGF1R

References

1. sabbatini p, rowand j l, groy a, et al. antitumor activity of gsk1904529a, a small-molecule inhibitor of the insulin-like growth factor-i receptor tyrosine kinase. clinical cancer research, 2009, 15(9): 3058-3067.

GSK1904529A Preparation Products And Raw materials

Raw materials

5-(3-(2-chloropyriMidin-4-yl)iMidazo[1,2-a]pyridin-2-yl)-N-(2,6-difluorophenyl)-2-MethoxybenzaMide 5-ethyl-2-Methoxy-4-(4-(4-(Methylsulfonyl)piperazin-1-yl)piperidin-1-yl)aniline

Preparation Products

GSK1904529A Suppliers

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29793 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Hubei Jusheng Technology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from GSK1904529A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK1904529A pictures 2024-11-19 GSK1904529A
1089283-49-7
 US $34.00-119.00 / mg 99% 10g TargetMol Chemicals Inc.
GSK1904529A pictures 2024-04-17 GSK1904529A
1089283-49-7
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
  • GSK1904529A pictures
  • GSK1904529A
    1089283-49-7
  • US $34.00-119.00 / mg
  • 99%
  • TargetMol Chemicals Inc.
  • GSK1904529A pictures
  • GSK1904529A
    1089283-49-7
  • US $1.10 / g
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd

GSK1904529A Spectrum

GSK1904529A(1089283-49-7)1HNMR

1089283-49-7(GSK1904529A)Related Search:

4-Aminodiphenylamine AZD-4547 Bortezomib MK-2206 2HCl PD 0332991 HCl
Crizotinib Olaparib

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GSK 4529 GSK1904529A GSK1904529A : IGF-IR, IGF-IIR inhibitor N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide GSK 1904529A GSK1904529A, >=98% IGF-IR, IGF-IIR inhibitor N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl] CS-29 GSK1904529A;GSK-1904529A;GSK 1904529A Benzamide, N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-methoxy- GSK1904529A ISO 9001：2015 REACH GSK1904529A (GSK-4529 N-(2,6-Difluorophenyl)-5-(3-(2-((5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide IGF-1R inhibitor GS1904529A 1089283-49-7 C44H47F2N9O5S Inhibitors