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F-AMidine

F-AMidine structure

CAS No.: 877617-45-3

Chemical Name:: F-AMidine

Synonyms: F-AMidine;F amidine,Famidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide;Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-

CBNumber:: CB92558584

Molecular Formula:: C14H19FN4O2

Molecular Weight:: 294.32

MDL Number:: MFCD28138492

MOL File:: 877617-45-3.mol

Last updated:2024-10-28 16:48:35

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F-AMidine Properties

Density	1.27±0.1 g/cm3(Predicted)
pka	13.26±0.46(Predicted)

F-AMidine price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F101250	F-Amidine	877617-45-3	2.5mg	$185	2021-12-16	Buy

Product number	Packaging	Price	Buy
F101250	2.5mg	$185	Buy

F-AMidine Chemical Properties,Uses,Production

Uses

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Definition

ChEBI: F-Amidine is a N-acylglycine.

F-AMidine Preparation Products And Raw materials

Raw materials

Preparation Products

F-AMidine Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19885	58
Guangzhou CATO Research Chemicals Inc.	+86-020-81960175-617 +8615602392859	Intermediate@cato-chem.com	China	8046	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	57412	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Guangzhou CATO Research Chemicals Inc.	58
J & K SCIENTIFIC LTD.	76
Chemsky (shanghai) International Co.,Ltd	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Energy Chemical	58
TargetMol Chemicals Inc.	58

View Lastest Price from F-AMidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	F-amidine 877617-45-3	US $1520.00-1980.00 / mg			10g	TargetMol Chemicals Inc.

F-amidine
877617-45-3
US $1520.00-1980.00 / mg
TargetMol Chemicals Inc.

F-AMidine N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide F amidine,Famidine Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]- 877617-45-3 Amines Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals