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ChemicalBook >> CAS DataBase List >> F-AMidine

F-AMidine

F-AMidine price.
  • $185
  • Product name: F-AMidine
  • CAS: 877617-45-3
  • MF: C14H19FN4O2
  • MW: 294.32
  • EINECS:
  • MDL Number:MFCD28138492
  • Synonyms:F-AMidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide;F amidine,Famidine;Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
Price1 Properties Safety Information Description
1 prices
Selected condition：
Brand
  • TRC
Package
  • 2.5mg
  • ManufacturerTRC
  • Product numberF101250
  • Product descriptionF-Amidine
  • Packaging2.5mg
  • Price$185
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TRC F101250 F-Amidine 2.5mg $185 2021-12-16 Buy

Properties

Density :1.27±0.1 g/cm3(Predicted)
pka :13.26±0.46(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Suppliers and manufacturers

TargetMol Chemicals Inc.
F-amidine
$1520.00 /25mg
F-amidine CAS:877617-45-3
TargetMol Chemicals Inc. J & K SCIENTIFIC LTD. Chemsky (shanghai) International Co.,Ltd Shenzhen Polymeri Biochemical Technology Co., Ltd. Energy Chemical TargetMol Chemicals Inc.