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Azelastine hydrochloride

CAS No.
79307-93-0
Chemical Name:
Azelastine hydrochloride
Synonyms
AZELASTINE HCL;Astelin;Optivar;1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride;4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1);Azen;a5610;e-0659;Azepit;w-2979m
CBNumber:
CB9256008
Molecular Formula:
C22H25Cl2N3O
Molecular Weight:
418.36
MDL Number:
MFCD00242783
MOL File:
79307-93-0.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22

Azelastine hydrochloride Properties

Melting point 225--2290C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: >10mg/mL
form powder
color white to off-white
Merck 14,906
Stability Incompatible with strong oxidizing agents.
InChI InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
InChIKey YEJAJYAHJQIWNU-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(Cl)C=C2)=NN1C1CCCN(C)CC1.[H]Cl
CAS DataBase Reference 79307-93-0(CAS DataBase Reference)
FDA UNII 0L591QR10I

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
RTECS  TH9203900
HS Code  2933992600
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel)
NFPA 704
0
2 0

Azelastine hydrochloride price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A7611 Azelastine hydrochloride ≥98% (HPLC) 79307-93-0 10mg $49.26 2024-03-01 Buy
Sigma-Aldrich A7611 Azelastine hydrochloride ≥98% (HPLC) 79307-93-0 50mg $130.4 2024-03-01 Buy
TCI Chemical A2340 Azelastine Hydrochloride >98.0%(HPLC)(T) 79307-93-0 1g $187 2024-03-01 Buy
TCI Chemical A2340 Azelastine Hydrochloride >98.0%(HPLC)(T) 79307-93-0 100mg $37 2024-03-01 Buy
Cayman Chemical 20873 Azelastine (hydrochloride) ≥98% 79307-93-0 5mg $36 2024-03-01 Buy
Product number Packaging Price Buy
A7611 10mg $49.26 Buy
A7611 50mg $130.4 Buy
A2340 1g $187 Buy
A2340 100mg $37 Buy
20873 5mg $36 Buy

Azelastine hydrochloride Chemical Properties,Uses,Production

Description

Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.

Chemical Properties

White or almost white, crystalline powder.

Originator

Asta-Werke(Degussa) (W. Germany)

Uses

Orally active H1-hystamine receptor antagonist. Antihistaminic

Application

Azelastine Hydrochloride is the hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity. Azelastine hydrochloride exhibits histamine H1-receptor antagonist activity in isolated tissues, animal models, and humans. Azelastine hydrochloride nasal solution is administered as a racemic mixture, and no difference in pharmacologic activity was noted between the enantiomers in vitro studies. The major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity. It competes with histamine for the H1 receptor, thereby diminishing the actions of histamine on effector cells and decreasing the histamine-mediated symptoms of allergic reaction, such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.

Definition

ChEBI: The hydrochloride salt of azelastine.

brand name

Astelin (Medpointe); Optivar (Medpointe);AZEPTIN.

General Description

(±)-4-[(4-chlorophenyl)methyl]-2-(hexahydro-l-methyl-1H-azepin-4-yl)-l-(2H)-phthalazinone monohydrochloride (Optivar), is a whitecrystalline powder that is sparingly soluble in water,methanol, and propylene glycol and slightly soluble inethanol, octanol, and glycerine. The commercial preparationis available as a 0.05% sterile ophthalmic solution fortopical administration to the eyes. Each milliliter of azelastinesolution contains 0.5-mg azelastine hydrochlorideequivalent to 0.457 mg of azelastine base, the preservativebenzalkonium chloride (0.125 mg), and inactive ingredientsincluding disodium edetate dihydrate, hydroxypropylmethylcellulose,sorbitol solution, sodium hydroxide, andwater for injection. The solution has a pH of approximately5.0 to 6.5 and an osmolality of approximately 271to 312 mOsm/L.
The recommended dose of azelastine solution is 1 dropinstilled into each affected eye twice a day. This drugproduct is for ocular administration only and not for injectionor oral use. Absorption of azelastine following ocularadministration is relatively low (less than 1 ng/rnL).Absorbed drug undergoes extensive oxidative N-demethylationby CYP, and the parent drug and metabolite are eliminatedprimarily in the feces. The most frequently reportedadverse reactions are transient eye burning or stinging,headaches, and bitter taste. Azelastine solution should beused with caution during pregnancy or while nursing, becauseits safety has not been studied under these circumstances.

Biochem/physiol Actions

H1 histamine receptor antagonist; NF-kB activator.

Safety Profile

Poison by ingestion andintravenous routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and HCl.

Azelastine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 398)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Qingdao Yonghefeng Economic and Trade Co., Ltd.
+86-13375559818 +86-13375559818 cfy69@163.com China 195 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
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career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
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Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
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Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15319487004 1015@dideu.com China 3209 58

Related articles

View Lastest Price from Azelastine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Azelastine hydrochloride pictures 2024-12-13 Azelastine hydrochloride
79307-93-0
US $0.00 / g/Bag 100g 99%min 300kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Azelastine hydrochloride pictures 2024-11-19 Azelastine hydrochloride
79307-93-0
US $45.00 / mL 99.97% 10g TargetMol Chemicals Inc.
Azelastine hydrochloride pictures 2024-11-19 Azelastine hydrochloride
79307-93-0
US $45.00 / mL 99.97% 10g TargetMol Chemicals Inc.

Azelastine hydrochloride Spectrum

a5610 azeptin e-0659 w-2979m AZELASTINE HYDROCHLORIDE 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride Allergodil Optilast Rhinolast Aselastine Acelastine hydrochloride Adomessen Asutoputin Azen Azepit Azelastine HCI Azelastine-d4 hydrochloride AZWLASTINE HYDROCHLORIDE API 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)-1-phthalazinone Hydrochloride Azelastine hydrochloride (Allergodil) Azelastine-d4 HCl Azelastine HCl (Allergodil) Azelastine hydrochloride CRS Azelastine Hydrochloride > 4-hydrazineyl-1-methylazepane hydrogen chloride 4-(4-Chlorobenzyl)-2-[(4RS)-1-methylhexahydro-1H-azepin-4-yl]phthalazin-1(2H)-one hydrochloride Azelastine hydrochloride USP/EP/BP Azelastine hydrochloride (API) Azelastine HydrochlorideQ: What is Azelastine Hydrochloride Q: What is the CAS Number of Azelastine Hydrochloride Q: What is the storage condition of Azelastine Hydrochloride Azelastine Hydrochloride (1046158) AZELASTINE HCL Astelin 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone, hydrochloride (1:1) Optivar 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one hydrochloride 79307-93-0 C22H24ClN3OHCl C22H27Cl2N3O C22H25Cl2N3O C22H24ClN3OClH Antihistaminic Astelin Intermediates & Fine Chemicals Pharmaceuticals Histamine receptor