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Rho Kinase Inhibitor V

Rho Kinase Inhibitor V Structure
Rho Kinase Inhibitor V structure
CAS No.
1072906-02-5
Chemical Name:
Rho Kinase Inhibitor V
Synonyms
Rho Kinase Inhibitor V;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem;1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]-
CBNumber:
CB92645099
Molecular Formula:
C18H15N3O3
Molecular Weight:
321.33
MDL Number:
MFCD28138106
MOL File:
1072906-02-5.mol
Last updated:2023-04-23 13:52:06
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Rho Kinase Inhibitor V Properties

Boiling point 638.4±55.0 °C(Predicted)
Density 1.374±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Light beige solid
pka 12.53±0.70(Predicted)

Rho Kinase Inhibitor V price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 555555 Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem 1072906-02-5 5mg $433 2023-06-20 Buy
Product number Packaging Price Buy
555555 5mg $433 Buy

Rho Kinase Inhibitor V Chemical Properties,Uses,Production

General Description

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC50 = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC50 = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC50 = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Rho Kinase Inhibitor V Preparation Products And Raw materials

Raw materials

Preparation Products

Rho Kinase Inhibitor V Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
VDM Biochemicals 64
Sigma-Aldrich 80
Rho Kinase Inhibitor V Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem 1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]- 1072906-02-5