Rho Kinase Inhibitor V

1072906-02-5

CAS-Nr.: 1072906-02-5

Englisch Name:: Rho Kinase Inhibitor V

Synonyma:: Rho Kinase Inhibitor V;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem;1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]-

CBNumber:: CB92645099

Summenformel:: C18H15N3O3

Molgewicht:: 321.33

MOL-Datei:: 1072906-02-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 15

Rho Kinase Inhibitor V Eigenschaften

Siedepunkt:: 638.4±55.0 °C(Predicted)

Dichte: 1.374±0.06 g/cm3(Predicted)

storage temp.: +2C to +8C

Aggregatzustand: Light beige solid

pka: 12.53±0.70(Predicted)

Sicherheit

Rho Kinase Inhibitor V Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC₅₀ = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC₅₀ = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC₅₀ = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Rho Kinase Inhibitor V Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Rho Kinase Inhibitor V Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 15)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Rho Kinase Inhibitor V
Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]-
1072906-02-5