ChemicalBook >> CAS DataBase List >>Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- structure

CAS No.: 1402612-58-1

Chemical Name:: Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-

Synonyms: ML295 (KT195);KT-195 (ML 295);KT195 >=98% (HPLC);[4-[4-(4-methoxyphenyl)phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone;4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone;Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-

CBNumber:: CB92668445

Molecular Formula:: C27H26N4O2

Molecular Weight:: 438.52

MDL Number:: MFCD26960821

MOL File:: 1402612-58-1.mol

Last updated:2023-06-08 09:03:09

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Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- Properties

solubility	DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml
form	A crystalline solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H413

Precautionary statements

P264-P270-P273-P301+P310-P321-P330-P405-P501

NFPA 704

	0
2		0

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14818	KT195 ≥98%	1402612-58-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	14818	KT195 ≥98%	1402612-58-1	5mg	$93	2024-03-01	Buy
Cayman Chemical	14818	KT195 ≥98%	1402612-58-1	10mg	$169	2024-03-01	Buy
Cayman Chemical	14818	KT195 ≥98%	1402612-58-1	25mg	$381	2024-03-01	Buy
ApexBio Technology	C3197	KT195	1402612-58-1	25mg	$435	2021-12-16	Buy

Product number	Packaging	Price	Buy
14818	1mg	$32	Buy
14818	5mg	$93	Buy
14818	10mg	$169	Buy
14818	25mg	$381	Buy
C3197	25mg	$435	Buy

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- Chemical Properties,Uses,Production

Description

The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG; ) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC₅₀ = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ. While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLβ. By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells. KT195 is also reported to reduce IL-1β secretion from lipopolysaccharide-treated macrophages.

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- Preparation Products And Raw materials

Raw materials

5-(4-bromophenyl)-1H-1,2,3-triazole

Preparation Products

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

Supplier	Advantage
SPIRO PHARMA	55
Shanghai EFE Biological Technology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
MedBioPharmaceutical Technology Inc	58
Energy Chemical	58
Changzhou Furuisi Biotechnology Co., Ltd	58
ApexBio Technology	58

Methanone, [4-(4'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- [4-[4-(4-methoxyphenyl)phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone KT-195 (ML 295) KT195 >=98% (HPLC) ML295 (KT195) 4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone 1402612-58-1