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ChemicalBook >> CAS DataBase List >>(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Structure
(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol structure
CAS No.
1397692-46-4
Chemical Name:
(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
Synonyms
Nat-20(S)-yne;Nat20(S)yne,Nat 20(S) yne;Nat-20(S)-yne Exclusive;SCMAJJQBADBBSM-CMJRPVKTSA-N;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)-;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol, CAS 1397692-46-4
CBNumber:
CB92694512
Molecular Formula:
C25H38O2
Molecular Weight:
370.57
MDL Number:
MOL File:
1397692-46-4.mol
Last updated:2024-10-23 13:36:13
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(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Properties

Boiling point 510.0±25.0 °C(Predicted)
Density 1.08±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 14 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid
pka 14.68±0.29(Predicted)

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9001369 Nat-20(S)-yne ≥95% 1397692-46-4 1mg $61 2024-03-01 Buy
Cayman Chemical 9001369 Nat-20(S)-yne ≥95% 1397692-46-4 5mg $264 2024-03-01 Buy
Cayman Chemical 9001369 Nat-20(S)-yne ≥95% 1397692-46-4 10mg $468 2024-03-01 Buy
Cayman Chemical 9001369 Nat-20(S)-yne ≥95% 1397692-46-4 25mg $1019 2024-03-01 Buy
TRC D480430 (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol 1397692-46-4 10mg $395 2021-12-16 Buy
Product number Packaging Price Buy
9001369 1mg $61 Buy
9001369 5mg $264 Buy
9001369 10mg $468 Buy
9001369 25mg $1019 Buy
D480430 10mg $395 Buy

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Chemical Properties,Uses,Production

Description

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

Uses

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is a byproduct of cholesterol (C432501) oxidation and a potential agonists of the hedgehog signaling pathway.

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Preparation Products And Raw materials

Raw materials

Preparation Products

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32297 58
J & K SCIENTIFIC LTD. 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8065 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57422 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24957 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Tanmo Quality Inspection Technology Co., Ltd. 4008-099-669 23419001name@qq.com CHINA 6043 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
J & K SCIENTIFIC LTD. 76
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Tanmo Quality Inspection Technology Co., Ltd. 58

View Lastest Price from (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nat-20(S)-yne pictures 2024-10-24 Nat-20(S)-yne
1397692-46-4
 US $153.00-1170.00 / mg 10g TargetMol Chemicals Inc.
  • Nat-20(S)-yne pictures
  • Nat-20(S)-yne
    1397692-46-4
  • US $153.00-1170.00 / mg
  • TargetMol Chemicals Inc.
(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol SCMAJJQBADBBSM-CMJRPVKTSA-N Nat-20(S)-yne Nat-20(S)-yne Exclusive 26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)- Nat20(S)yne,Nat 20(S) yne (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol, CAS 1397692-46-4 1397692-46-4 Pharmaceuticals, Intermediates & Fine Chemicals, Steroids