(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Struktur
1397692-46-4
CAS-Nr.
1397692-46-4
Englisch Name:
(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
Synonyma:
Nat-20(S)-yne;Nat20(S)yne,Nat 20(S) yne;Nat-20(S)-yne Exclusive;SCMAJJQBADBBSM-CMJRPVKTSA-N;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)-
CBNumber:
CB92694512
Summenformel:
C25H38O2
Molgewicht:
370.57
MOL-Datei:
1397692-46-4.mol

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Eigenschaften

Siedepunkt:
510.0±25.0 °C(Predicted)
Dichte
1.08±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMF: 14 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 10 mg/ml
Aggregatzustand
A crystalline solid
pka
14.68±0.29(Predicted)

Sicherheit

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

Verwenden

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is a byproduct of cholesterol (C432501) oxidation and a potential agonists of the hedgehog signaling pathway.

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 24)Lieferanten
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TargetMol Chemicals Inc.
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
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Shanghai Hongye Biotechnology Co. Ltd 400-9205774
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TargetMol Chemicals Inc. 4008200310
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Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11974 58
4008-099-669
23419001name@qq.com CHINA 68144 58

  • (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
  • SCMAJJQBADBBSM-CMJRPVKTSA-N
  • Nat-20(S)-yne
  • Nat-20(S)-yne Exclusive
  • 26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)-
  • Nat20(S)yne,Nat 20(S) yne
  • (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol
  • 1397692-46-4
  • Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
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