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(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol 구조식 이미지

카스 번호:: 1397692-46-4

상품명:: (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol

동의어(영문):: Nat-20(S)-yne;Nat20(S)yne,Nat 20(S) yne;Nat-20(S)-yne Exclusive;SCMAJJQBADBBSM-CMJRPVKTSA-N;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)-

CBNumber:: CB92694512

분자식:: C25H38O2

포뮬러 무게:: 370.57

MOL 파일:: 1397692-46-4.mol

속성

안전

용도

공급 업체 24

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol 속성

끓는 점: 510.0±25.0 °C(Predicted)

밀도: 1.08±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 14 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 10 mg/ml

물리적 상태: 결정성 고체

산도 계수 (pKa): 14.68±0.29(Predicted)

안전

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol C화학적 특성, 용도, 생산

개요

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC₅₀ = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

용도

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is a byproduct of cholesterol (C432501) oxidation and a potential agonists of the hedgehog signaling pathway.

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol 준비 용품 및 원자재

원자재

준비 용품

(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol 공급 업체

글로벌( 24)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32038	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8065	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	56604	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24649	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
	4008-099-669	23419001name@qq.com	CHINA	68144	58