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ASP-9521

ASP-9521 Structure
ASP-9521 structure
CAS No.
1126084-37-4
Chemical Name:
ASP-9521
Synonyms
ASP-9521;ASP-9521, >98%;17HSD5 inhibitor;AKR1C3 inhibitor;ASP 9521. AKR1C3 inhibitor;Inhibitor,inhibit,ASP-9521,ASP 9521;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
CBNumber:
CB92731017
Molecular Formula:
C19H26N2O3
Molecular Weight:
330.42
MDL Number:
MFCD30532740
MOL File:
1126084-37-4.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:41
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ASP-9521 Properties

Boiling point 543.9±30.0 °C(Predicted)
Density 1.183±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM)
form A crystalline solid
pka 15.23±0.29(Predicted)
color Light yellow to yellow
FDA UNII AA79G37CPR

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

ASP-9521 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27308 ASP9521 1126084-37-4 10mg $92 2024-03-01 Buy
Cayman Chemical 27308 ASP9521 1126084-37-4 25mg $166 2024-03-01 Buy
Cayman Chemical 27308 ASP9521 1126084-37-4 5mg $62 2024-03-01 Buy
Tocris 6084 ASP9521 ≥98%(HPLC) 1126084-37-4 10 $68 2021-12-16 Buy
Tocris 6084 ASP9521 ≥98%(HPLC) 1126084-37-4 50 $284 2021-12-16 Buy
Product number Packaging Price Buy
27308 10mg $92 Buy
27308 25mg $166 Buy
27308 5mg $62 Buy
6084 10 $68 Buy
6084 50 $284 Buy

ASP-9521 Chemical Properties,Uses,Production

Description

ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC50 = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.

Uses

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer

ASP-9521 Preparation Products And Raw materials

Raw materials

Preparation Products

ASP-9521 Suppliers

Global( 60)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30240 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Career Henan Chemica Co 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Shanghai Boyle Chemical Co., Ltd. 55

View Lastest Price from ASP-9521 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ASP-9521 pictures 2024-10-22 ASP-9521
1126084-37-4
 US $1.00 / g 1g Min98% HPLC/GC g/kg/ton Coreychem-Nicole Career Henan Chemica Co
  • ASP-9521 pictures
  • ASP-9521
    1126084-37-4
  • US $1.00 / g
  • Min98% HPLC/GC
  • Career Henan Chemica Co

1126084-37-4(ASP-9521)Related Search:

6-Methoxyindole 3,4,5-Trimethoxybenzoyl chloride
ASP-9521 1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol AKR1C3 inhibitor ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR [4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone 17HSD5 inhibitor ASP 9521. AKR1C3 inhibitor ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR ASP-9521, >98% Methanone, [4-(2-hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)- (4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone Inhibitor,inhibit,ASP-9521,ASP 9521 1126084-37-4