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DBCO-maleimide

CAS No.
1395786-30-7
Chemical Name:
DBCO-maleimide
Synonyms
Dibenzocyclooctyne-maleimide;DBCO-MAL;DBCO-maleimide;DBCO-Maleimide,Dibenzocyclooctyne-maleimide;DBCO-maleimide (This product is unavailable in the U.S.);DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5);Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.);1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo-;N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide;N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-(2,5-dioxopyrrol-1-yl)propanamide
CBNumber:
CB92985649
Molecular Formula:
C25H21N3O4
Molecular Weight:
427.45
MDL Number:
MFCD22380750
MOL File:
1395786-30-7.mol
MSDS File:
SDS
Last updated:2024-10-28 23:16:16

DBCO-maleimide Properties

Melting point 162 °C
Boiling point 790.5±60.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO, DCM, DMF
pka 15.03±0.46(Predicted)
form Solid
color Off-white to Gray

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50
Safety Statements  61

DBCO-maleimide price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 760668 Dibenzocyclooctyne-maleimide for Copper-free Click Chemistry 1395786-30-7 1MG $32.8 2023-06-20 Buy
Sigma-Aldrich 760668 Dibenzocyclooctyne-maleimide for Copper-free Click Chemistry 1395786-30-7 5MG $101 2023-06-20 Buy
Sigma-Aldrich 760668 Dibenzocyclooctyne-maleimide for Copper-free Click Chemistry 1395786-30-7 50MG $393 2023-06-20 Buy
TRC A939575 Dbco-Maleimide 1395786-30-7 1mg $40 2021-12-16 Buy
Chem-Impex 35063 DBCOmaleimide,95%(HPLC) 95%(HPLC) 1395786-30-7 5MG $56 2021-12-16 Buy
Product number Packaging Price Buy
760668 1MG $32.8 Buy
760668 5MG $101 Buy
760668 50MG $393 Buy
A939575 1mg $40 Buy
35063 5MG $56 Buy

DBCO-maleimide Chemical Properties,Uses,Production

Description

DBCO-Maleimide is a sulfhydryl reactive reagent containing a maleimide group and a DBCO moiety. Maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Dbco-Maleimide is used in preparation of radioactive metal indicator-chelating peptide derivative-conjugated antibodies for medical imaging.

Uses

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

DBCO-maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

DBCO-maleimide Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
9i LLC
+18039569191 MWan@NiNeiLab.com United States 418 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Hangzhou Huarong Pharm Co., Ltd.
571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58
ChemExpress
+86-021-58950125 +86-021-58950125; info@chemexpress.com China 781 58
Henan Alfa Chemical Co., Ltd
China 11415 58
Labnetwork lnc.
+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630 bess@weibangbio.com China 18151 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58

View Lastest Price from DBCO-maleimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DBCO-Maleimide pictures 2024-10-28 DBCO-Maleimide
1395786-30-7
US $247.00-65.00 / mg 10g TargetMol Chemicals Inc.
DBCO-Maleimide pictures 2024-03-20 DBCO-Maleimide
1395786-30-7
US $0.00 / mg 25mg >98.00% 250 Xian confluore Biological Technology Co., Ltd.
  • DBCO-Maleimide pictures
  • DBCO-Maleimide
    1395786-30-7
  • US $247.00-65.00 / mg
  • TargetMol Chemicals Inc.
  • DBCO-Maleimide pictures
  • DBCO-Maleimide
    1395786-30-7
  • US $0.00 / mg
  • >98.00%
  • Xian confluore Biological Technology Co., Ltd.
DBCO-maleimide Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.) 1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo- DBCO-Maleimide,Dibenzocyclooctyne-maleimide DBCO-maleimide (This product is unavailable in the U.S.) DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5) N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide Dibenzocyclooctyne-maleimide DBCO-MAL N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-(2,5-dioxopyrrol-1-yl)propanamide 1395786-30-7 ADC LINKER