ICA 110381
- CAS No.
- 325457-99-6
- Chemical Name:
- ICA 110381
- Synonyms
- ICA-11038;ICA 110381;ICA 110381; ICA110381;ICA 110381 (Compound 16);4-CHLOR-N-(6-CHLOR-PYRIDIN-3-YL)-BENZAMID;4-Chloro-N-(6-chloro-3-pyridinyl)benzamide;4-Chloro-N-(6-chloro-pyridin-3-yl)-benzamide;Benzamide, 4-chloro-N-(6-chloro-3-pyridinyl)-;inhibit,ICA 110381,Potassium Channel,ICA-110381,KcsA,ICA110381,Inhibitor
- CBNumber:
- CB93037314
- Molecular Formula:
- C12H8Cl2N2O
- Molecular Weight:
- 267.11
- MDL Number:
- MFCD05669575
- MOL File:
- 325457-99-6.mol
- MSDS File:
- SDS
| Boiling point | 336.8±37.0 °C(Predicted) |
|---|---|
| Density | 1.440±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml). |
| form | solid |
| pka | 11.34±0.70(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ICA 110381 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4950 | ICA110381 ≥98%(HPLC) | 325457-99-6 | 10 | $154 | 2021-12-16 | Buy |
| Tocris | 4950 | ICA110381 ≥98%(HPLC) | 325457-99-6 | 50 | $628 | 2021-12-16 | Buy |
| TRC | I163600 | ICA110381 | 325457-99-6 | 100mg | $1095 | 2021-12-16 | Buy |
| Usbiological | 255482 | ICA 110381 | 325457-99-6 | 10mg | $403 | 2021-12-16 | Buy |
| Usbiological | 452171 | ICA 110381 | 325457-99-6 | 10mg | $425 | 2021-12-16 | Buy |
ICA 110381 Chemical Properties,Uses,Production
Description
ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1?KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity?in vivo.2
Uses
ICA 110381 was used to study the pharmacological activities as it selectively activated human KCNQ2 expressed in Chinese hamster ovary, damped neuronal excitability in rat hippocampal CA1 cell and showed anticonvulsant activity in amygdala-kindled rat.
storage
Store at +4°C
References
1) Amato?et al. (2011),?N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett.,?2?481 2) Boehlen?et al. (2013),?The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol.,?168?1182
ICA 110381 Preparation Products And Raw materials
Raw materials
Preparation Products
ICA 110381 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30254 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |