Tos-PEG2-CH2CO2tBu
- CAS No.
- 1643957-24-7
- Chemical Name:
- Tos-PEG2-CH2CO2tBu
- Synonyms
- Tos-PEG1-CH2-Boc;Tos-PEG2-CH2CO2tBu;Tos-PEG1-CH2COOtBu;tert-Butyl 2-[2-(tosyloxy)ethoxy]acetate;Tert butyl 2- (2- (p-toluenesulfonyloxy) ethoxy) acetate;Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester
- CBNumber:
- CB93062686
- Molecular Formula:
- C15H22O6S
- Molecular Weight:
- 330.4
- MDL Number:
- MFCD28122953
- MOL File:
- 1643957-24-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Tos-PEG2-CH2CO2tBu price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-22282 | Tos-PEG2-CH2CO2tBu 98% | 1643957-24-7 | 250mg | $350 | 2021-12-16 | Buy |
| BroadPharm | BP-22282 | Tos-PEG2-CH2CO2tBu 98% | 1643957-24-7 | 1g | $890 | 2021-12-16 | Buy |
| BroadPharm | BP-22282 | Tos-PEG2-CH2CO2tBu 98% | 1643957-24-7 | 2g | $1325 | 2021-12-16 | Buy |
| A1 Biochem Labs | 6588175 | tert-Butyl2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate 95% | 1643957-24-7 | 5G | $1250 | 2021-12-16 | Buy |
| Ambeed | A966140 | tert-Butyl2-[2-(tosyloxy)ethoxy]acetate 95+% | 1643957-24-7 | 1g | $603 | 2021-12-16 | Buy |
Tos-PEG2-CH2CO2tBu Chemical Properties,Uses,Production
Description
Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG2-CH2CO2tBu Preparation Products And Raw materials
Raw materials
Preparation Products
Tos-PEG2-CH2CO2tBu Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28803 | 58 |
| Aikon International Limited | 025-66061636 18013972705 | cfzhang@aikonchem.com | China | 15818 | 58 |