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SR-95531

CAS No.
104104-50-9
Chemical Name:
SR-95531
Synonyms
GABAZINE;SR-95531;GABAZINE BROMIDE;SR 95531 hydrobromid;SR 95531 HYDROBROMIDE;Gabazine Hydrobromide;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531);4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
CBNumber:
CB9356638
Molecular Formula:
C15H18BrN3O3
Molecular Weight:
368.23
MDL Number:
MFCD09055424
MOL File:
104104-50-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

SR-95531 Properties

Melting point 200 °C(Solv: ethanol (64-17-5))
storage temp. Store at RT
solubility DMSO: 30 mg/mL
form solid
color white
EWG's Food Scores 1
FDA UNII 99460MG420

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3

SR-95531 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S106 SR-95531 ≥98% (HPLC), powder 104104-50-9 50mg $644 2024-03-01 Buy
Sigma-Aldrich 5.05986 SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem 104104-50-9 10mg $155 2024-03-01 Buy
Cayman Chemical 14585 SR 95531 (hydrobromide) ≥98% 104104-50-9 5mg $73 2024-03-01 Buy
Cayman Chemical 14585 SR 95531 (hydrobromide) ≥98% 104104-50-9 10mg $116 2024-03-01 Buy
Sigma-Aldrich S106 SR-95531 ≥98% (HPLC), powder 104104-50-9 10mg $191 2024-03-01 Buy
Product number Packaging Price Buy
S106 50mg $644 Buy
5.05986 10mg $155 Buy
14585 5mg $73 Buy
14585 10mg $116 Buy
S106 10mg $191 Buy

SR-95531 Chemical Properties,Uses,Production

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABAA receptor isoforms from mice, rats, and humans.

Uses

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

storage

Room temperature

SR-95531 Preparation Products And Raw materials

Raw materials

Preparation Products

SR-95531 Suppliers

Global( 89)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32760 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Hunan Jibang Biological Technology Co., LTD
+8613776644403 sales02@kingboomtech.com China 1806 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 4692 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94717 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide 1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide 6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide Gabazine Hydrobromide 4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide GABAZINE BROMIDE 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE 6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE SR 95531 HYDROBROMIDE SR-95531 SR 95531 hydrobromide NEW SR 95531 hydrobromid Gabazine bromide (SR95531) 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid GABAZINE Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531 104104-50-9 104105-50-9 C15H17N3O3HBr C15H18BrN3O3 C15H18N3O3Br Cell Biology Cell Signaling and Neuroscience BioChemical Ion Channels Ligand-Gated Ion Channels GABA and Glycine Receptor Modulators GABA/Glycine receptor