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| | SR-95531 Basic information |
| Product Name: | SR-95531 | | Synonyms: | Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide;1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide;6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br;6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide;Gabazine Hydrobromide;4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide;GABAZINE BROMIDE;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM | | CAS: | 104104-50-9 | | MF: | C15H18BrN3O3 | | MW: | 368.23 | | EINECS: | | | Product Categories: | GABA/Glycine receptor | | Mol File: | 104104-50-9.mol |  |
| | SR-95531 Chemical Properties |
| Melting point | 200 °C(Solv: ethanol (64-17-5)) | | storage temp. | Store at RT | | solubility | DMSO: 30 mg/mL | | form | solid | | color | white |
| | SR-95531 Usage And Synthesis |
| Description | SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABAA receptor isoforms from mice, rats, and humans. | | Uses | Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites. | | Biological Activity | Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist. | | Biochem/physiol Actions | SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities. | | storage | Room temperature |
| | SR-95531 Preparation Products And Raw materials |
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