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Meclizine dihydrochloride

CAS No.
1104-22-9
Chemical Name:
Meclizine dihydrochloride
Synonyms
diadril;bonamine;NSC 28728;Navidoxine;Meclozine Hcl;)-4-(3-methyL;Meclizine 2HCl;Meclizine diHCl;Meclozine ,Bonamine;ancolandihydrochloride
CBNumber:
CB9362486
Molecular Formula:
C25H29Cl3N2
Molecular Weight:
463.87
MDL Number:
MFCD00058199
MOL File:
1104-22-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:32

Meclizine dihydrochloride Properties

Melting point 210.0 to 214.0 °C
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
color white to beige
CAS DataBase Reference 1104-22-9(CAS DataBase Reference)
FDA UNII L997QXC9J1
EPA Substance Registry System Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361
Precautionary statements  P201-P301+P312+P330-P308+P313
Hazard Codes  Xn
Risk Statements  22-63
Safety Statements  22-36
WGK Germany  3
RTECS  TL2005000
HS Code  2933.59.8000
Toxicity LD50 oral in mouse: 1600mg/kg
NFPA 704
0
1 0

Meclizine dihydrochloride price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0950 Meclizine dihydrochloride ≥97% (HPLC) 1104-22-9 50mg $116 2024-03-01 Buy
Sigma-Aldrich M0220000 Meclozine dihydrochloride European Pharmacopoeia (EP) Reference Standard 1104-22-9 m0220000 $150 2024-03-01 Buy
Sigma-Aldrich BP220 Meclozine hydrochloride British Pharmacopoeia (BP) Reference Standard 1104-22-9 100MG $266 2024-03-01 Buy
TCI Chemical M2755 Meclizine Dihydrochloride >98.0%(HPLC) 1104-22-9 5g $71 2024-03-01 Buy
TCI Chemical M2755 Meclizine Dihydrochloride >98.0%(HPLC) 1104-22-9 25g $210 2023-06-20 Buy
Product number Packaging Price Buy
SML0950 50mg $116 Buy
M0220000 m0220000 $150 Buy
BP220 100MG $266 Buy
M2755 5g $71 Buy
M2755 25g $210 Buy

Meclizine dihydrochloride Chemical Properties,Uses,Production

Description

Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.

Chemical Properties

White or yellowish-white, slightly hygroscopic, crystalline powder.

Originator

Antivert,Roerig,US,1957

Uses

Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.

Uses

cholinergic, diagnostic aid

Uses

Antiemetic;Histamine antagonist

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

Biochem/physiol Actions

Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

Solubility in organics

Meclizine dihydrochloride is readily soluble in chloroform and pyridine, slightly soluble in dilute acids and ethanol, and insoluble in water or ether.

storage

Desiccate at RT

Meclizine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 290)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460 faith@widelychemical.com CHINA 742 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211 info@longyupharma.com China 2542 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21142 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

View Lastest Price from Meclizine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Meclizine dihydrochloride pictures 2024-11-19 Meclizine dihydrochloride
1104-22-9
US $50.00 / mg 99.79% 10g TargetMol Chemicals Inc.
Meclizine dihydrochloride pictures 2024-11-19 Meclizine dihydrochloride
1104-22-9
US $50.00 / mg 99.79% 10g TargetMol Chemicals Inc.
Meclizine dihydrochloride pictures 2021-07-13 Meclizine dihydrochloride
1104-22-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Meclizine dihydrochloride Spectrum

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride Meclozine Hcl 1-((4-Chlorophenyl)(phenyl)Methyl)-4-(3-Methylbenzyl)piperazine dihydrochloride Meclizine 2HCl Piperazine,1-[(4-chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]-, hydrochloride(1:2) 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazine,hydrochloride (1:2) 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride 1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride ancolandihydrochloride bonamine diadril MECLIZINE DIHYDROCHLORIDE 1-([4-CHLOROPHENYL]PHENYLMETHYL)-4-([3-METHYLPHENYL]-METHYL)PIPERAZINE DIHYDROCHLORIDE 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-piperazindih 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazindihydrochlorid 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazindihyd Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (9CI) Postafene dihydrochloride Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride meclozinedihydrochloride parachloraminedihydrochloride Meclozine dihydrochloride monohydrate Meclizine diHCl 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride mecilizine hydrochloride Navidoxine NSC 28728 Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI) 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)p Meclozine ,Bonamine MeclizineDihydrochloride> Meclozine dihydrochloride CRS )piperazine dihydrochL )-4-(3-methyL 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine Dihydrochloride Meclizine dihydrochloride USP/EP/BP 1104-22-9 C25H27Cl2N22HCl C25H27ClN22ClH C25H29Cl3N2 C25H27ClN22HCl PROVOCHOLINE