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Benznidazole

CAS No.
22994-85-0
Chemical Name:
Benznidazole
Synonyms
ro71051;radanil;Rochagan;Aids007909;NSC 299972;Ro 07-1051;Aids-007909;Benznidazol;benznidazole;Benzonidazol
CBNumber:
CB9390906
Molecular Formula:
C12H12N4O3
Molecular Weight:
260.25
MDL Number:
MFCD00243089
MOL File:
22994-85-0.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Benznidazole Properties

Melting point 189-192 °C (lit.)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility methanol: soluble50mg/mL, clear, colorless to yellow
pka 14?+-.0.46(Predicted)
form Solid
color White to Off-White
Water Solubility 0.4g/L(temperature not stated)
Merck 13,1085
BCS Class 3
FDA UNII YC42NRJ1ZD
ATC code P01CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  NI3340000
NFPA 704
0
2 0

Benznidazole price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 419656 N-Benzyl-2-nitro-1H-imidazole-1-acetamide 97% 22994-85-0 1g $262 2024-03-01 Buy
Cayman Chemical 29090 Benznidazole 22994-85-0 25mg $106 2024-03-01 Buy
Cayman Chemical 29090 Benznidazole 22994-85-0 250mg $723 2024-03-01 Buy
Cayman Chemical 29090 Benznidazole 22994-85-0 50mg $198 2024-03-01 Buy
Cayman Chemical 29090 Benznidazole 22994-85-0 100mg $352 2024-03-01 Buy
Product number Packaging Price Buy
419656 1g $262 Buy
29090 25mg $106 Buy
29090 250mg $723 Buy
29090 50mg $198 Buy
29090 100mg $352 Buy

Benznidazole Chemical Properties,Uses,Production

Description

Benznidazole is the second of the drugs approved for treatment of Chagas' disease. Like nifurtimox, it is effective against the circulating form of Trypanosoma cruzi during the acute phase of the disease, but also like nifurtimox, it is ineffective during the chronic stage of the disease.

Description

Benznidazole is an orally bioavailable antiprotozoal agent. It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite. It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively). It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM. Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease. Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.

Uses

Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever e side effects.

Uses

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) may be used as reference drug for the extraction of guaianolide from the aerial parts of Tanacetum parthenium and to evaluate its in vitro antiprotozoal activity.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.

Antimicrobial activity

It exhibits antiprotozoal activity, particularly against Trypanosoma cruzi.

General Description

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..

Pharmaceutical Applications

A synthetic 2-nitroimidazole, formulated for oral administration. Solubility in water 400 mg/L.

Mechanism of action

Studies suggest that benznidazole does not catalyze the formation of ROS and, therefore, has a mechanism of action different from that of nifurtimox. It has been proposed that benznidazole undergoes an one-electron transfer to the nitro group, which in turn dismutates to give back the nitroimidazole and a nitrosoimidazole. The latter product may then undergo an electrophilic addition to trypanothione, which leads to depletion of trypanothione, an essential enzyme system in the Trypanosoma cruzi.

Pharmacokinetics

Oral bioavailability :High
Cmax 100 mg oral :2.2–2.8 mg/L after 3–4 h
Plasma half-life:10.5–13.6 h
Volume of distribution:c. 0.56 L/kg
Plasma protein binding: c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.

Clinical Use

N-Benzyl-2-nitroimidazole-1-acetamide (Radanil, Rochagan)is a nitroimidazole derivative that is used for the treatment ofChagas disease. It is not available in the United States but isused extensively in South America. The effectiveness of benznidazoleis similar to that of nifurtimox. Therapy forAmerican trypanosomiasis with oral benznidazole requiresseveral weeks and is frequently accompanied by adverse effectssuch as peripheral neuropathy, bone marrow depression,and allergic-type reactions.

Clinical Use

Benznidazole is used in treatment of South American trypanosomiasis (Chagas disease).

Side effects

Adverse effects are more common in the elderly and include nausea, vomiting, abdominal pain, peripheral neuropathy and severe skin reactions.

Benznidazole Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 96)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma Audley
+86-15937194204 +86-18126314766 nova@sh-teruiop.com China 467 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Hong Kong Excellence Biotechnology Co., Ltd.
ada@sh-teruiop.com China 875 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38632 58

View Lastest Price from Benznidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Benznidazol pictures 2024-11-19 Benznidazol
US $31.00-48.00 / mg 99.79% 10g TargetMol Chemicals Inc.
Benznidazole pictures 2024-03-12 Benznidazole
22994-85-0
US $35.00-25.00 / kg 1kg 99.8% 200tons/year Sigma Audley
Benznidazole pictures 2019-12-26 Benznidazole
22994-85-0
US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co
  • Benznidazol pictures
  • Benznidazol
  • US $31.00-48.00 / mg
  • 99.79%
  • TargetMol Chemicals Inc.
  • Benznidazole pictures
  • Benznidazole
    22994-85-0
  • US $35.00-25.00 / kg
  • 99.8%
  • Sigma Audley
  • Benznidazole pictures
  • Benznidazole
    22994-85-0
  • US $1.00 / g
  • ≥98%
  • Career Henan Chemical Co

Benznidazole Spectrum

n-benzyl-2-(nitroimidazol-1-yl)-acetamid n-benzyl-2-nitro-1-imidazoleacetamide n-benzyl-2-nitro-imidazole-1-acetamid n-benzyl-2-nitroimidazole-1-acetamide benznidazole benzonidazole radanil ro71051 BenznidazoleBenznidazole Benzonidazol N-BENZYL-2-NITRO-1 H-IMIDAZOLE-1-ACETAMIDE Aids007909 Aids-007909 Benznidazol N-Benzyl-2-nitroiMidazol-1-yl-acetaMide NSC 299972 Ro 07-1051 Rochagan 1H-IMidazole-1-acetaMide, 2-nitro-N-(phenylMethyl)- N-Benzyl-2-nitro-1H-imidazole-1-acetamide 97% 2-nitro-n-(phenylmethyl)-1h-imidazole-1-acetamid 2-nitro-n-(phenylmethyl)-1h-imidazole-1-acetamide Benznidazol (Ro 07-1051 Benznidazol (Synonyms: Ro 07-1051 BENZNIDAZOLE (Ro 07-1051) Benznidazol CAS NO.22994-85-0 Benznidazol,Ro71051,inhibit,Inhibitor,Parasite,Ro-71051 22994-85-0 Imidazoles Heterocyclic Building Blocks Building Blocks Heterocyclic Compounds Building Blocks Heterocyclic Building Blocks Imidazoles