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Dinoprost tromethamine

CAS No.
38562-01-5
Chemical Name:
Dinoprost tromethamine
Synonyms
583e;u14585;lutalyse;Ensaprost;u-14,583e;PGF2ALPHA;PGF2αTris;Zinoprost;haminesalt;PGF2a-THAM
CBNumber:
CB9394313
Molecular Formula:
C24H45NO8
Molecular Weight:
475.62
MDL Number:
MFCD00077863
MOL File:
38562-01-5.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Dinoprost tromethamine Properties

Melting point 100-101°
storage temp. -20°C
solubility H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
form powder
color white
Merck 13,7970
BRN 4087514
Stability Hygroscopic
InChIKey IYGXEHDCSOYNKY-RZHHZEQLSA-N
FDA UNII CT6BBQ5A68
NCI Drug Dictionary dinoprost tromethamine

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360FD
Precautionary statements  P202-P264-P270-P280-P301+P312-P308+P313
Hazard Codes  T
Risk Statements  60-22
Safety Statements  53-45
WGK Germany  3
RTECS  UK8025000
8-10
HS Code  2937500000
NFPA 704
0
2 0

Dinoprost tromethamine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0424 Prostaglandin F2α tris salt ≥99%, synthetic, powder 38562-01-5 1mg $150 2024-03-01 Buy
Sigma-Aldrich 1213001 Dinoprost tromethamine United States Pharmacopeia (USP) Reference Standard 38562-01-5 50mg $1396 2024-03-01 Buy
Alfa Aesar J67245 Prostaglandin F2alpha tris salt, 99% 38562-01-5 1mg $69.9 2023-06-20 Buy
Alfa Aesar J67245 Prostaglandin F2alpha tris salt, 99% 38562-01-5 5mg $283 2023-06-20 Buy
Cayman Chemical 16020 Prostaglandin F2α (tromethamine salt) ≥99% 38562-01-5 1mg $33 2024-03-01 Buy
Product number Packaging Price Buy
P0424 1mg $150 Buy
1213001 50mg $1396 Buy
J67245 1mg $69.9 Buy
J67245 5mg $283 Buy
16020 1mg $33 Buy

Dinoprost tromethamine Chemical Properties,Uses,Production

Description

Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.

Chemical Properties

White Solid

Originator

Prostin F2A,Upjohn,UK,1972

Uses

One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.

Indications

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

Definition

dinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.

Manufacturing Process

A solution of tris(hydroxymethyl)aminomethane (1.645 grams) in 3.0 ml of water at 60°C is added with vigorous stirring to a solution of PGF2α, (5.00 grams) in 700 ml of acetonitrile which has just been
ought to its boiling point. The vessel which contained the aqueous amine solution is rinsed with three 0.66 ml portions of water, each rinsing being added with vigorous stirring to the acetonitrile solution. The mixture is then cooled to 25°C by immersion of the vessel in cool water. At the cloud point, the vessel wall (glass) below the liquid surface is scratched vigorously with a glass rod. The mixture is then maintained at 25°C for 24 hours.
The resulting crystals are collected by filtration under nitrogen, washed on the filter with 50 ml of acetonitrile, and then dried by passing nitrogen at 50°C through the filter cake for one hour. Drying is completed in an oven at 70°C for 8 hours to give 5.965 grams of the tris(hydroxymethyl)aminomethane salt of PGF2α in free flowing crystalline form; MP 100°-101°C.

brand name

Prostin F2 Alpha (Pharmacia & Upjohn).

Therapeutic Function

Smooth muscle stimulant

Biochem/physiol Actions

Prostaglandin F2α is induced by uterine-produced oxytocin and acts on the corpus luteum to cause luteolysis and inhibit progesterone production.

Safety Profile

Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also other prostaglandin entries.

storage

Store at -20°C

551-11-1
77-86-1
38562-01-5
Synthesis of Dinoprost tromethamine from Prostaglandin F2a and Tris(hydroxymethyl)aminomethane

Dinoprost tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 260)Suppliers
Supplier Tel Email Country ProdList Advantage
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829 mack@tongyon.com China 2994 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 988 58
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+undefined17712220823 admin@guyunchem.com China 615 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 FandaChem@Gmail.com China 9084 55
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705 CHINA 139 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

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View Lastest Price from Dinoprost tromethamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dinoprost Tromethamine pictures 2024-12-24 Dinoprost Tromethamine
38562-01-5
US $0.00-0.00 / Kg/Bag 1Kg/Bag EP9.0, GMP, DMF 20 tons Sinoway Industrial co., ltd.
Dinoprost tromethamine salt pictures 2024-11-19 Dinoprost tromethamine salt
38562-01-5
US $33.00-77.00 / mg 99.73% 10g TargetMol Chemicals Inc.
Dinoprost tromethamine pictures 2024-09-25 Dinoprost tromethamine
38562-01-5
US $15.00 / gram 10gram 99% 50000 kilograms Wuhan Senwayer Century Chemical Co.,Ltd

Dinoprost tromethamine Spectrum

583e 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet Tromethamine salt PGF2α (Prostaglandin F2α) Dinoprost TroMethaMine USP Dinorprost tromethamine (E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) Ensaprost Dinoprost Tromethamine (50 mg) (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid 2-AMino-2-(hydroxyMethyl)-1,3-propanediol 7-[3,5-Dihydroxy-2-(3-hydroxy-1- octenyl)cyclopentyl]-5-heptenoic Acid TroMethaMine 9α,11α,15(S)-Trihydroxy-5-cis-13-trans-prostadienoic Acid TroMethaMine 9α,11α-PGF2 TroMethaMine 9α,11α-PGF2α TroMethaMine thampgf2-alpha tromethamineprostaglandinf2-alpha u-14,583e u14585 PROSTAGLANDINS F2ALPHA TRIS SALT PROSTAGLANDIN F2-ALPHA, TRIMETHAMINE SALT PROSTAGLANDIN F2ALPHA TRIS SALT PROSTAGLANDIN F2ALPHA TROMETHAMINE PROSTAGLANDIN F2ALPHA TROMETHAMINE SALT prostaglandin f2a tris salt PGF2ALPHA PGF2ALPHA THAM PGF2ALPHA-TRIS PGF2ALPHA TRIS SALT 9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic acid tris(hydroxymethyl)aminomethane salt 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacitham compd.withtrimethylolaminomethane haminesalt 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, TRIS(HYDROXYMETHYL) AMINOMETHANE SALT (5z,9a,11a,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt Tromethamine prostaglandin F2α PGF2a-THAM PGF2α-Tris, Prostaglandin F2α tris salt, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2α-Tris, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2αTris lutalyse pgf2-alphatromethamine pgf2-alphatromethaminesalt prostaglandinf2-alphatham prostaglandinf2-alphathamsalt prostaglandinf2atromethamine protaglandinf2-alpha-thamsalt DINOPROST TROMETHAMINE DINOPROST (TROMETHAMINE SALT) dinoprost, trometamol salt prostaglandin F2A tris prostaglandin F2-alpha, trometamol salt PROSTAGLANDIN F2A TRIS GAMMA-IRRADIATED CELL CULTUR PROSTAGLANDIN F2A TRIS CELL*CULTURE TEST ED [5Z,9ALPHA,11ALPHA,13E,15S]-9,11,15-TRIHYDROXYPROSTA-5,13-DIENOIC ACID TRIS SALT Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) (5z,9α,11α,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oate (salt) (9CI)