SB216763
- CAS No.
- 280744-09-4
- Chemical Name:
- SB216763
- Synonyms
- CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
- CBNumber:
- CB9493416
- Molecular Formula:
- C19H12Cl2N2O2
- Molecular Weight:
- 371.22
- MDL Number:
- MFCD09753369
- MOL File:
- 280744-09-4.mol
- MSDS File:
- SDS
| Melting point | 287-288.6 °C(lit.) |
|---|---|
| Boiling point | 598.1±50.0 °C(Predicted) |
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | Orange solid |
| pka | 7.27±0.60(Predicted) |
| color | orange |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SB216763 price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S3442 | SB 216763 >98% (HPLC) | 280744-09-4 | 5mg | $178 | 2024-03-01 | Buy |
| Sigma-Aldrich | S3442 | SB 216763 >98% (HPLC) | 280744-09-4 | 25mg | $708 | 2024-03-01 | Buy |
| TCI Chemical | B5716 | SB 216763 >98.0%(HPLC) | 280744-09-4 | 10mg | $118 | 2024-03-01 | Buy |
| TCI Chemical | B5716 | SB 216763 >98.0%(HPLC) | 280744-09-4 | 50mg | $352 | 2024-03-01 | Buy |
| Cayman Chemical | 10010246 | SB 216763 ≥98% | 280744-09-4 | 5mg | $73 | 2024-03-01 | Buy |
SB216763 Chemical Properties,Uses,Production
Description
SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.
Uses
SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.
Uses
SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.
Definition
ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
Biochem/physiol Actions
SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
storage
Room temperature
References
1) Coghlan et al. (2000), Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription; Chem. Biol., 7 793 2) Gurrieri et al. (2010), 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis; J. Pharmacol. Exp. Ther., 332 785 3) Cross et al. (2001), Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death; J. Neurochem., 77 94 4) Kirby et al. (2012), Glycogen synthase kinase 3 (GSK3) inhibitor , SB-216763, promotes pluripotency in mouse embryonic stem cells; PLoS One, 7 e39329
SB216763 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from SB216763 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | SB 216763
280744-09-4
|
US $33.00-72.00 / mg | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-25 | SB216763
280744-09-4
|
US $19.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | SB216763
280744-09-4
|
US $19.00 / KG | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |