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COMBRETASTATIN A-4

COMBRETASTATIN A-4 structure

CAS No.: 117048-59-6

Chemical Name:: COMBRETASTATIN A-4

Synonyms: CA4;CS-A4;CS-284;CRC 87-09;NSC 817373;NSC-817373;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4

CBNumber:: CB9496826

Molecular Formula:: C18H20O5

Molecular Weight:: 316.35

MDL Number:: MFCD03453309

MOL File:: 117048-59-6.mol

MSDS File:: SDS

Last updated:2024-11-20 11:41:24

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COMBRETASTATIN A-4 Properties

Melting point	84.5-85.5°C
Boiling point	490.3±45.0 °C(Predicted)
Density	1.184±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: >10mg/mL
pka	9.65±0.10(Predicted)
form	powder
color	off-white
Merck	14,2494
FDA UNII	16U6OP69RQ

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301+H311+H331-H318

Precautionary statements

P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338

Hazard Codes

Risk Statements

23/24/25-41

Safety Statements

26-36/37-39-45

RIDADR

UN 2811

WGK Germany

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

29095000

NFPA 704

	0
4		0

COMBRETASTATIN A-4 price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C7744	Combretastatin A4 ≥98% (HPLC), powder	117048-59-6	5mg	$70.2	2024-03-01	Buy
Sigma-Aldrich	234200	Combretastatin A-4	117048-59-6	10mg	$230	2024-03-01	Buy
TCI Chemical	C2520	Combretastatin A4 >98.0%(HPLC)	117048-59-6	25mg	$135	2024-03-01	Buy
TCI Chemical	C2520	Combretastatin A4 >98.0%(HPLC)	117048-59-6	250mg	$812	2024-03-01	Buy
Cayman Chemical	10007412	Combrestatin A4 ≥98%	117048-59-6	5mg	$63	2024-03-01	Buy

Product number	Packaging	Price	Buy
C7744	5mg	$70.2	Buy
234200	10mg	$230	Buy
C2520	25mg	$135	Buy
C2520	250mg	$812	Buy
10007412	5mg	$63	Buy

COMBRETASTATIN A-4 Chemical Properties,Uses,Production

Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC₅₀ values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC₅₀ value of 2.2 μM.

Chemical Properties

Crystalline Powder

Uses

Combretastatin A4 has been used:

as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Definition

ChEBI: Combretastatin A4 is a stilbenoid.

General Description

Combretastatin A4 belong to the class of colchicinoids compounds.

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

Biochem/physiol Actions

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

Anticancer Research

It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).

COMBRETASTATIN A-4 Preparation Products And Raw materials

Raw materials

Isovanillin Copper Quinoline Acetic anhydride Triethylamine

3,4,5-Trimethoxyphenylacetic acid Hydrochloric acid

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Preparation Products

COMBRETASTATIN A-4 Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2993	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Biochempartner	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Xi'an Kono chem co., Ltd.,	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58

View Lastest Price from COMBRETASTATIN A-4 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Combretastatin A4 117048-59-6	US $50.00 / mg		99.81%	10g	TargetMol Chemicals Inc.
2024-08-24	COMBRETASTATIN A-4 117048-59-6	US $0.10 / KG	1KG	98.0%	10	Shaanxi Dideu Medichem Co. Ltd
2024-03-28	Combretastatin A4 117048-59-6	US $0.00 / kg	25kg	98%	Inquiry	PNP Biotech Co. Ltd

Combretastatin A4
117048-59-6
US $50.00 / mg
99.81%
TargetMol Chemicals Inc.

COMBRETASTATIN A-4
117048-59-6
US $0.10 / KG
98.0%
Shaanxi Dideu Medichem Co. Ltd

Combretastatin A4
117048-59-6
US $0.00 / kg
98%
PNP Biotech Co. Ltd

COMBRETASTATIN A-4 Spectrum

COMBRETASTATIN A-4(117048-59-6)¹HNMR

117048-59-6(COMBRETASTATIN A-4)Related Search:

2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Hydroxyecdysone Artemether beta-Sitosterol alpha-Terpineol

hydroxygenkwanin MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one 4-Hydroxyphenethyl alcohol

Combretastatin A4 phosphate disodium salt COMBRETASTATIN A-4 COMBRETASTATIN A1 (Z)-3-Ethoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol BENZENEACETIC ACID, 3-HYDROXY-4-METHOXY-A-[(3,4,5-TRIMETHOXYPHENYL)METHYLENE]-, (AE)-

2,3-DIMETHOXY-5-[(Z)-2-(4-METHOXY-3-(2-[2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-4-YL)OXY)ETHOXY]ETHOXY)PHENYL)ETHENYL]PHENYL METHYL ETHER Combretastatin A-1 di-O-phosphate tetra-sodium salt 3-(3-Hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-acrylic acid

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(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4 Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol ) (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98% 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol 5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol Combretastatin A4 (Z)-CombretastatinA4 combretastatin A-4 (CA-4) 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol Combrestatin A4 (Z)-2-Methoxy-5-[2-(3,4,5-triMethoxyphenyl)ethenyl]phenol, 3,4,5-TriMethoxy-3'-hydroxy-4'-Methoxy-(Z)-stilbene CS-A4 CoMbretastatin A CA-4, Combretastatin A-4 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene CA4 (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol Combretastatin A4 117048-59-6 Combretastatin A-4 - CAS 117048-59-6 - Calbiochem CS-284 CRC 87-09 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z Combretastatin A4 (CRC 87-09) Combretastatin A4 > Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]- Recombinant Human Carbonic Anhydrase IV/CA4 Protein, His Tag 3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene Combretastatin TXB-4 NSC 817373 NSC-817373 117048-59-6 17048-59-6 Inhibitors Combretastatin API Anti-cancer & immunity