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PD 173074

PD 173074 structure

CAS No.: 219580-11-7

Chemical Name:: PD 173074

Synonyms: CS-458;PD176074;PD-0173074;PD173074, >=98%;PD173074/PD-173074;PD 173074, Free Base;Cholest-5-en-3-ol,(9α)-;PD-173074 FGFR1 FGFR3 inhibitor ab141117;FGF/VEGF Receptor Tyrosine Kinase Inhibitor;FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074

CBNumber:: CB9497090

Molecular Formula:: C28H41N7O3

Molecular Weight:: 523.67

MDL Number:: MFCD08705327

MOL File:: 219580-11-7.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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PD 173074 Properties

Melting point	82-85°C
Density	1.163
storage temp.	2-8°C
solubility	DMSO: 21 mg/mL
form	solid
pka	10.12±0.43(Predicted)
color	yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII	A4TLL8634Y

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P271

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

HS Code

2933599590

NFPA 704

	0
2		0

PD 173074 price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P2499	PD 173074 ≥96% (HPLC), powder	219580-11-7	5mg	$279	2024-03-01	Buy
Sigma-Aldrich	341607	FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074	219580-11-7	5mg	$475	2024-03-01	Buy
TCI Chemical	P2474	PD 173074 >95.0%(HPLC)	219580-11-7	10mg	$139	2024-03-01	Buy
TCI Chemical	P2474	PD 173074 >95.0%(HPLC)	219580-11-7	50mg	$416	2024-03-01	Buy
Cayman Chemical	13032	PD 173074 ≥98%	219580-11-7	5mg	$39	2024-03-01	Buy

Product number	Packaging	Price	Buy
P2499	5mg	$279	Buy
341607	5mg	$475	Buy
P2474	10mg	$139	Buy
P2474	50mg	$416	Buy
13032	5mg	$39	Buy

PD 173074 Chemical Properties,Uses,Production

Description

PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1?(IC50?values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3

Chemical Properties

Yellow Solid

Uses

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

Uses

A selective FGFR1 and

Uses

PD 173074 ar signal-related kinase phosphorylation.

Definition

ChEBI: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at pos tions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.

Biological Activity

Selective FGFR1 and FGFR3 inhibitor (IC 50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors.

Biochem/physiol Actions

PD 173074 is a fibroblast growth factor receptor 3 (FGFR3) inhibitor: IC50 = 5 nM inhibition of FGFR3 autophosphorylation. PD 173074 arrests the G0/G1 phase of FGFR3-expressing cells. It is 100-fold more selective for FGFR3 than for VEGF receptors, IGF-1 receptors, and MAPKs.

in vitro

pd173074 was found to block h-510 and h-69 sclc proliferation and clonogenic growth in a dose-dependent fashion and prevent fgf-2-induced chemoresistance as well. these effects correlate with the inhibition of both fgfr1 and fgfr2 transphosphorylation. in addition, pd173074 showed a high degree of selectivity for fgfr tyrosine kinase [2].

in vivo

in the h-510 xenograft mouse model, tumor growth was significanlty improved similar to that seen with single-agent cisplatin administration. accordingly, pd173074 treatment resulted in significanlty prolonged median survival when compared with that of control sham-treated animals. more dramatically, pd173074 also induced complete responses lasting >6 months in 50% of in mice h-69 xenografts [2].

storage

+4°C

References

1 Bansal?et al. (2003),?Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res.,?74?486 2) Kim?et al. (2012),?Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs; Biotechnol. Prog.,?28?1384 3) Zaragosi?et al. (2006),?Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells,?24?2412

PD 173074 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 173074 Suppliers

Global( 165)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9214	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58

View Lastest Price from PD 173074 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	PD173074 219580-11-7	US $36.00-91.00 / mg		98.21%	10g	TargetMol Chemicals Inc.
2022-09-08	PD 173074 219580-11-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	PD 173074 219580-11-7	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

PD173074
219580-11-7
US $36.00-91.00 / mg
98.21%
TargetMol Chemicals Inc.

PD 173074
219580-11-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

PD 173074
219580-11-7
US $1.00 / KG
98%
Career Henan Chemical Co

PD 173074 Spectrum

PD 173074(219580-11-7)¹HNMR

219580-11-7(PD 173074)Related Search:

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1of4

n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)- PD173074/PD-173074 1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin- Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)- PD176074 N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074 PD 173074 N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD-0173074 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimid FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 PD 173074, Free Base PD173074, >=98% CS-458 FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem FGF/VEGF Receptor Tyrosine Kinase Inhibitor PD 173074;PD-173074;FGF/VEGF RECEPTOR TYROSINE KINASE INHIBITOR 1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea Cholest-5-en-3-ol,(9α)- PD-173074 FGFR1 FGFR3 inhibitor ab141117 Inhibitor,Fibroblast growth factor receptor,PD173074,Apoptosis,Vascular endothelial growth factor receptor,inhibit,PD 173074,FGFR,PD-173074,VEGFR N-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea 219580-11-7 C28H41N7O3 Antineoplastic API Aromatics Bases & Related Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Nucleotides Pharmaceuticals