BI-749327
- CAS No.
- 2361241-23-6
- Chemical Name:
- BI-749327
- Synonyms
- BI-749327;BI-749327, 10 mM in DMSO;(4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone;Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-;BI749327,Inhibitor,BI-749327,inhibit,Transient receptor potential channels,BI 749327,TRP Channel
- CBNumber:
- CB95419686
- Molecular Formula:
- C23H21F3N4O2
- Molecular Weight:
- 442.43
- MDL Number:
- MFCD32062737
- MOL File:
- 2361241-23-6.mol
| Boiling point | 637.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.334±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (25 mg/ml) |
| form | solid |
| pka | 5.26±0.10(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
BI-749327 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0094062 | BI-749327 99.53% | 2361241-23-6 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0094062 | BI-749327 99.53% | 2361241-23-6 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0094062 | BI-749327 99.53% | 2361241-23-6 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0094062 | BI-749327 99.53% | 2361241-23-6 | 100mg | $2650 | 2021-12-16 | Buy |
| DC Chemicals | DC42750 | BI-749327 >98% | 2361241-23-6 | 1g | $2400 | 2021-12-16 | Buy |
BI-749327 Chemical Properties,Uses,Production
Description
BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models.? BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2
References
Lin et al. (2019) In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease; Proc. Natl. Acad. Sci. USA 116 10156 Jain et al. (2021) TRPC6, a therapeutic target for pulmonary hypertension; Am. J. Physiol. Lung Cell. Mol. Physiol. 321 L1161
BI-749327 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-749327 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19186 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
