(R)-1-BOC-3-(Hydroxymethyl)piperazine
- CAS No.
- 278788-66-2
- Chemical Name:
- (R)-1-BOC-3-(Hydroxymethyl)piperazine
- Synonyms
- tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-1-Boc-3-(hyroxyMethyl)piperazine
- CBNumber:
- CB9715509
- Molecular Formula:
- C10H20N2O3
- Molecular Weight:
- 216.28
- MDL Number:
- MFCD05863888
- MOL File:
- 278788-66-2.mol
- MSDS File:
- SDS
Melting point | 68-70°C |
---|---|
Boiling point | 322.9±22.0 °C(Predicted) |
Density | 1.085±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 14.97±0.10(Predicted) |
color | White to Off-White |
InChI | InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1 |
InChIKey | NSILYQWHARROMG-MRVPVSSYSA-N |
SMILES | N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1 |
CAS DataBase Reference | 278788-66-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311+H331-H315-H319 |
Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
Hazard Codes | Xi |
Risk Statements | 41-52 |
Safety Statements | 26-39 |
HS Code | 2933599590 |
(R)-1-BOC-3-(Hydroxymethyl)piperazine price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SYX00408 | (R)-1-BOC-3-(Hydroxymethyl)piperazine | 278788-66-2 | 1g | $461 | 2024-03-01 | Buy |
Activate Scientific | AS3141 | (R)-1-Boc-(3-Hydroxymethyl)piperazine 95+% ee | 278788-66-2 | 25g | $476 | 2021-12-16 | Buy |
AK Scientific | X4711 | (R)-3-Hydroxymethyl-piperazine-1-carboxylicacidtert-butylester | 278788-66-2 | 10g | $517 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CCH0037750 | (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% | 278788-66-2 | 1G | $526 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB151258 | (R)-4-N-Boc-2-hydroxymethyl-piperazine | 278788-66-2 | 2g | $619 | 2021-12-16 | Buy |
(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Uses,Production
Uses
(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.
Synthesis
1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 | shangli@bocchem.com | China | 138 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9338 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29901 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7239 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-08-06 | (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
278788-66-2
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
- (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
278788-66-2
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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