BUTYROLACETONE 3
- CAS No.
- 778649-18-6
- Chemical Name:
- BUTYROLACETONE 3
- Synonyms
- Butyrolactone 3;BUTYROLACETONE 3;GCN5 INHIBITOR 1;3-Furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2R,3S)-rel-
- CBNumber:
- CB9848548
- Molecular Formula:
- C9H12O4
- Molecular Weight:
- 184.19
- MDL Number:
- MFCD08702690
- MOL File:
- 778649-18-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| WGK Germany | nwg | |||||||||
| NFPA 704 |
|
BUTYROLACETONE 3 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 12095 | Butyrolactone 3 ≥95% | 778649-18-6 | 1mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 12095 | Butyrolactone 3 ≥95% | 778649-18-6 | 5mg | $155 | 2024-03-01 | Buy |
| TRC | B761010 | Butyrolactone3 | 778649-18-6 | 50mg | $1315 | 2021-12-16 | Buy |
| Usbiological | 207098 | Butyrolactone 3 | 778649-18-6 | 2mg | $325 | 2021-12-16 | Buy |
| ChemScene | CS-0103268 | Butyrolactone3 ≥98.0% | 778649-18-6 | 10mg | $400 | 2021-12-16 | Buy |
BUTYROLACETONE 3 Chemical Properties,Uses,Production
Uses
Butyrolactone 3 is a selective inhibitor of histone acetyltransferase Gcn5 with affinity for the enzyme comparable to its natural substrate. Butyrolactone 3 is very useful tool in understanding and further studying the histone code.
Definition
ChEBI: (2S,3R)-4-methylene-5-oxo-2-propyl-3-oxolanecarboxylic acid is a gamma-lactone.
in vitro
the analogs of butyrolactone 3 only showed a weak inhibition of cbp, while butyrolactone 3 led to an inhibition of gcn5. it was important to see that in the presence of acetyl-coa the kd value for binding of histone h3 to gcn5 or pcaf was around 100 mm. moreover, the affinity of butyrolactone 3 to the gcn5 enzyme was found to be comparable to that of the natural substrate h3 and could provide an good starting point for the study of sar. in addition, a nonirreversible inhibition of gcn5 could be determine, and thus a michael addition of nucleophilic groups of the enzymebs active side was unlikely. therefore, the derivatization of gbutyrolactone 3 at position 2 might be a promising starting point for future sar studies [1].
IC 50
100 μm
References
1. m. biel, a. kretsovali, e. karatzali, et al. design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase gcn5. angewandte chemie international edition 43, 3974-3976 (2004).
BUTYROLACETONE 3 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56070 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |