chlorthenoxazine
- CAS No.
- 132-89-8
- Chemical Name:
- chlorthenoxazine
- Synonyms
- Ap 67;Valtorin;Valmorin;Piroxina;Ossazone;Apirazin;chlorthenoxazin;chlorthenoxazine;Chlorethylbenzmethoxazone;Chlorthenoxazine,inhibit,Inhibitor
- CBNumber:
- CB9899858
- Molecular Formula:
- C12H8ClNO
- Molecular Weight:
- 217.65102
- MDL Number:
- MFCD00012095
- MOL File:
- 132-89-8.mol
- MSDS File:
- SDS
Melting point | 146-147° (dec) |
---|---|
Boiling point | 303°C (rough estimate) |
Density | 1.2414 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
pka | 12.70±0.40(Predicted) |
FDA UNII | KA0B657LV3 |
chlorthenoxazine Chemical Properties,Uses,Production
Originator
Reugaril ,Farber ,Italy ,1966
Definition
ChEBI: Chlorthenoxazine is a benzoxazine.
Manufacturing Process
A mixture of 4 liters chloroform and 1,050 cc ethanol was saturated with dry hydrogen chloride gas at -5°C to +5°C in a vessel having a net volume of 15 liters and provided with a stirring device, reflux cooler, gas feed line, thermometer and dropping funnel. 455 g acrolein which had been precooled to 0°C were added dropwise to the solution over a period of 1 to 2 hours while maintaining the temperature below +5°C and vigorously stirring. 1,070 g salicylamide and 1,080 g glacial acetic acid were added to the resulting solution of beta-chloropropionaldehyde acetal, thereby forming a suspension which was heated to 60°C while stirring. A clear solution was formed which was maintained at 60°C for an additional hour. The solution was allowed to cool to about 40°C and was then washed with water by passing a strong stream of water under the surface of the chloroform and continuously withdrawing the upper phase. When the water had reached a pH of 3-4, the precipitated reaction product was separated by vacuum filtration. The chloroform phase of the filtrate was evaporated under a weak vacuum and the residue was combined with the precipitate first obtained. The combined products were stirred with 2 liters of a 5% sodium hydroxide solution. The raw reaction product was then washed with water, dried and recrystallized from ethanol. The product had the melting point of 146°C to 147°C (decomposition). The yield was 1,260 g, corresponding to 76% of the theoretical yield.
Therapeutic Function
Antipyretic, Analgesic
chlorthenoxazine Preparation Products And Raw materials
chlorthenoxazine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Aikon International Limited | 025-66113011 18112977050 | cb6@aikonchem.com | China | 15495 | 58 |
Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9527 | 58 |
Amel Pharmatech Corporation | 888-4366503 | sales@amelpharmatech.com | China | 4128 | 58 |
Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
Shanghai Hecheng Medical Technology Co., LTD | 13564747822 | 669027880@qq.com | China | 917 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9973 | 58 |
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