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H-89 DIHYDROCHLORIDE HYDRATE

H-89 DIHYDROCHLORIDE HYDRATE structure

CAS No.: 130964-39-5

Chemical Name:: H-89 DIHYDROCHLORIDE HYDRATE

Synonyms: H 89 2HCl;H-89, PKA inhibitor;5-Isoquinolinesulfonamide;H-89 DIHYDROCHLORIDE HYDRATE;H-89 hydrate dihydrochloride;H-89 dihydrochloride, 10 mM in DMSO;H89 dihydrochloride, Kinase inhibitor;H-89 DIHYDROCHLORIDE HYDRATE USP/EP/BP;Protein kinase inhibitor H-89 dihydrochloride;H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Et

CBNumber:: CB9972711

Molecular Formula:: C20H20BrN3O2S.2ClH.H2O

Molecular Weight:: 537.304

MDL Number:: MFCD00214120

MOL File:: 130964-39-5.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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H-89 DIHYDROCHLORIDE HYDRATE Properties

Melting point	195-200°C
storage temp.	Inert atmosphere,2-8°C
solubility	H2O: ≥10mg/mL
form	powder
color	off-white
biological source	synthetic (organic)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
Safety Statements	22-24/25
WGK Germany	3
HS Code	2935909099

H-89 DIHYDROCHLORIDE HYDRATE price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B1427	H-89 dihydrochloride hydrate ≥98% (HPLC), powder	130964-39-5	5mg	$193	2024-03-01	Buy
Cayman Chemical	10010556	H-89 (hydrochloride) ≥98%	130964-39-5	5mg	$49	2024-03-01	Buy
Cayman Chemical	10010556	H-89 (hydrochloride) ≥98%	130964-39-5	10mg	$92	2024-03-01	Buy
Cayman Chemical	10010556	H-89 (hydrochloride) ≥98%	130964-39-5	25mg	$216	2024-03-01	Buy
Cayman Chemical	10010556	H-89 (hydrochloride) ≥98%	130964-39-5	50mg	$356	2024-03-01	Buy

Product number	Packaging	Price	Buy
B1427	5mg	$193	Buy
10010556	5mg	$49	Buy
10010556	10mg	$92	Buy
10010556	25mg	$216	Buy
10010556	50mg	$356	Buy

H-89 DIHYDROCHLORIDE HYDRATE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Uses

Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.

Definition

ChEBI: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride is a hydrochloride salt prepared from N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide and two equivalents of hydrogen chloride. It has a role as an EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor. It contains a N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide(2+).

Biological Activity

h 89 2hcl is a potent pka inhibitor. in a cell-free assay, the ki of h 89 is 48 nm, 10-fold selective for pka than pkg and 500-fold greater selectivity than pkc, mlck, calmodulin kinase ii and casein kinase i/ii [1].[1]. chijiwa t, mishima a, hagiwara m, et al. inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic amp-dependent protein kinase, n-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (h-89), of pc12d pheochromocytoma cells[j]. journal of biological chemistry, 1990, 265(9): 5267-5272.[2]. lochner a, moolman j a. the many faces of h89: a review[j]. cardiovascular drug reviews, 2006, 24(3‐4): 261-274.[3]. lee t h, linstedt a d. potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-golgi transport revealed by protein kinase inhibitor h89[j]. molecular biology of the cell, 2000, 11(8): 2577-2590.

Biochem/physiol Actions

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K+) current in rat myocytes. It mediates Na+ transport by interacting with α subunits of epithelial Na+ channel (ENaC).

in vitro

in pc12d cells, pretreatment with h-89 dose-dependently inhibited the forskolin-induced protein phosphorylation, with no influence in intracellular cyclic amp levels. in pc12d cells, h-89 significantly inhibited the forskolin-induced neurite outgrowth. in pc12d cells, pretreatment with h-89 (30 μm) strikingly inhibited camp-dependent histone iib phosphorylation activity in cell lysates while showed no effects on other protein phosphorylation activity such as cgmp-dependent histone iib phosphorylation activity [1]. h 89 was a potent and selective pka inhibitor with ki of 48 nm in a cell-free assay [2]. h89 also inhibited s6k1, msk1, pka, rockii, pkbα and mapkap-k1b kinases with ic50 of 80, 120, 135, 270, 2600 and 2800 nm, respectively [2]. in the hypotonic medium, 50 μm h89, a concentration commonly used to inhibit pka, prevented the redistribution response. in normal medium, h89 (50 μm) induced the redistribution of ergic 53 to the er by 20 min [3].

storage

-20°C

H-89 DIHYDROCHLORIDE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

H-89 DIHYDROCHLORIDE HYDRATE Suppliers

Global( 136)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9642	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nanjing Doge Biomedical Technology Co., Ltd	58

View Lastest Price from H-89 DIHYDROCHLORIDE HYDRATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	H-89 dihydrochloride 130964-39-5	US $33.00-108.00 / mg		99.4%	10g	TargetMol Chemicals Inc.

H-89 dihydrochloride
130964-39-5
US $33.00-108.00 / mg
99.4%
TargetMol Chemicals Inc.

H-89 DIHYDROCHLORIDE HYDRATE Spectrum

H-89 DIHYDROCHLORIDE HYDRATE(130964-39-5)¹HNMR

130964-39-5(H-89 DIHYDROCHLORIDE HYDRATE)Related Search:

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Forskolin N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

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H-89 DIHYDROCHLORIDE HYDRATE H-89 hydrate dihydrochloride H-89 dihydrochloride hydrate,N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride 5-IsoquinolinesulfonaMide, N-[2-[[3-(4-broMophenyl)-2-propenyl]aMino]ethyl]-, dihydrochloride N-[2-[[3-(4-BroMophenyl)-2-propen-1-yl]aMino]ethyl]-5-isoquinolinesulfonaMide Hydrochloride H 89 2HCl Protein kinase inhibitor H-89 dihydrochloride (E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Et N-[2-[[3-(4-Bromophenyl)-2-Propen-1-Yl]Amino]Ethyl]-5-Isoquinolinesulfonamide Hydrochloride (1:2) PROTEIN KINASE INHIBITOR H-89 DIHYDROCHLORIDE; H89 DIHYDROCHLORIDE;H 89 H-89 dihydrochloride(Protein kinase inhibitor H-89 dihydrochloride) PROTEIN KINASE INHIBITOR H-89 DIHYDROCHLORIDE;H89 DIHYDROCHLORIDE;H 89 DIHYDROCHLORIDE;H 89;H89 5-Isoquinolinesulfonamide H-89 DIHYDROCHLORIDE HYDRATE USP/EP/BP Protein kinase inhibitor H-89 dihydrochloride|||H 89 2HCl|||5-Isoquinolinesulfonamide H-89, PKA inhibitor H89 dihydrochloride, Kinase inhibitor H-89 dihydrochloride, 10 mM in DMSO 130964-39-5 Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR Protein Kinase Inhibitors and Activators