PHENYL-D5-BORONIC ACID
- CAS No.
- 215527-70-1
- Chemical Name:
- PHENYL-D5-BORONIC ACID
- Synonyms
- 2,3,4,5,6-Pentadeuteriumbenzeneboronic Acid;9-bromo-10-(phenyl-d5)anthracene;PHENYL-D5-BORONIC ACID;Phenyl-d?-boronic acid;B-(phenyl-2,3,4,5,6-d5)-;Deuterated phenylboronic acid;phenyl-d5-boronicacid98atom%d;PHENYL-D5-BORONIC ACID(D, 98%);(Perdeuterophenyl)boronic acid;B-(Phenyl-2,3,4,5,6-d5)boronic acid
- CBNumber:
- CB0121981
- Molecular Formula:
- C6H7BO2
- Molecular Weight:
- 121.93
- MOL File:
- 215527-70-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/26 17:21:34
| Melting point | 217-220 °C(lit.) |
|---|---|
| solubility | Chloroform (Slightly), DMSO |
| form | solid |
| color | White |
| Stability | Hygroscopic |
| InChI | InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H |
| InChIKey | HXITXNWTGFUOAU-RALIUCGRSA-N |
| SMILES | B(C1C([H])=C([H])C([H])=C([H])C=1[H])(O)O |
| CAS DataBase Reference | 215527-70-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P280-P321-P362+P364 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| HS Code | 2931900090 |
PHENYL-D5-BORONIC ACID Chemical Properties,Uses,Production
Uses
Phenylboronic Acid-d5 is the isotope labelled analog of Phenylboronic Acid; a compound used in the organic synthesis of various pharmaceutical goods.
Synthesis
A dry three-neck flask equipped with a rubber septum, an addition funnel equipped with a rubber septum, and a condenser was charged under nitrogen with magnesium turnings. To the addition funnel was added D5-bromobenzene (6.5 mL, 62 mmol) (Aldrich) dissolved in a 1:1 mixture of THF/toluene (31 mL). Grignard reagent formation was observed after about after about 1 mL of the contents of the addition funnel had been added to the magnesium turnings. The remaining bromobenzene solution was added dropwise over a period of about 1 h. After the addition was complete the reaction mixture was heated at 70° C. for 1 h. The reaction mixture was cooled to room temperature and added via a canulating needled to an addition funnel on a second three-neck flask containing a solution of triethylborate (B(OEt)3) (10.5 mL, 62 mmol) in toluene (10 mL) maintained at 0° C. The solution of the freshly prepared Grignard reagent was then added dropwise to the solution of triethylborate over a period of 1 h. The cooling bath was then removed and the reaction mixture was allowed to stir at room temperature for 15 h. The reaction mixture was quenched with 10% H2SO4 (30 mL) and stirred at room temperature for 1 h. The layers were separated and the organic layer was dried over Na2SO4. After removal of the solvent, addition of hexane precipitated the product as an off-white solid, which was collected by filtration and dried to afford Phenyl-d5-boronic acid. Its yield: 3.50 g, 45%.
PHENYL-D5-BORONIC ACID Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Peric Technology Co.,Ltd | +86-0310-7183483 +8615030098277 | China | 36 | 58 | Inquiry |
| Yurui (Shanghai) Chemical Co., Ltd. | +86-021-50456736 +8615000292053 | China | 942 | 58 | Inquiry |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | China | 1227 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 6938 | 58 | Inquiry |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | China | 1092 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20361 | 58 | Inquiry |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | China | 2068 | 57 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
215527-70-1(PHENYL-D5-BORONIC ACID)Related Search:
1of3
chevron_right