15-KETO PROSTAGLANDIN E2

15-KETO PROSTAGLANDIN E2 Structure
CAS No.
26441-05-4
Chemical Name:
15-KETO PROSTAGLANDIN E2
Synonyms
15-KetoPGE2;15-Oxoprostaglandin E2;15-KETO PROSTAGLANDIN E2;15-Dehydroprostaglandin E2;Dinoprostone EP Impurity F;15-keto Prostaglandin E2 MaxSpecStandard;Alprostadil (Prostaglandin E1) Impurity 6;15-keto Prostaglandin E2 Lipid Maps MS Standard;9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;(5Z,13E)-9,15-Dioxo-11α-hydroxyprosta-5,13-diene-1-oic acid
CBNumber:
CB0125323
Molecular Formula:
C20H30O5
Molecular Weight:
350.45
MOL File:
26441-05-4.mol
Modify Date:
2024/7/2 8:54:56

15-KETO PROSTAGLANDIN E2 Properties

Boiling point 534.4±50.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
form A crystalline solid
pka 4.75±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
NFPA 704
0
2 0

15-KETO PROSTAGLANDIN E2 Chemical Properties,Uses,Production

Uses

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).[Cayman Chemical]

15-KETO PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-7-[(1R,2S,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid 11-Hydroxy-9,15-dioxo-[5Z,11α,13E]-prosta-5,13-dien-1-oic acid: 15-Dehydroprostaglandin E2 (5Z,11R,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid (5Z,13E)-11α-Hydroxy-9,15-dioxo-5,13-prostadiene-1-oic acid (5Z,13E)-9,15-Dioxo-11α-hydroxyprosta-5,13-diene-1-oic acid 15-KetoPGE2 15-Oxoprostaglandin E2 15-keto Prostaglandin E2 Lipid Maps MS Standard 11-Hydroxy-9,15-dioxo-[5Z,11α,13E]-prosta-5,13-dien-1-oic acid 15-Dehydroprostaglandin E2 15-KETO PROSTAGLANDIN E2 9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID 15-keto Prostaglandin E2 MaxSpecStandard Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)- Dinoprostone EP Impurity F (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-3-oxo-oct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid (15-oxo-PGE2 Alprostadil (Prostaglandin E1) Impurity 6 Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)- 26441-05-4