1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
![1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Structure](CAS/GIF/23007-85-4.gif)
- CAS No.
- 23007-85-4
- Chemical Name:
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Synonyms
- MPTP;MPTP HCl;MPTP HYDROCHLORIDE;Methyl Hydrochloride;23007-85-4/28289-54-5;NSC 139654 Hydrochloride;Pethidine EP Impurity B HCl;1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&;1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinehydr;MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem
- CBNumber:
- CB0133791
- Molecular Formula:
- C12H16ClN
- Molecular Weight:
- 209.72
- MOL File:
- 23007-85-4.mol
- Modify Date:
- 2024/5/24 13:24:25
Melting point | 249.0 to 254.0 °C |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | White solid |
color | white to off-white |
BRN | 3707312 |
Stability | Light Sensitive |
InChI | InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H |
InChIKey | KOWJANGMTAZWDT-UHFFFAOYSA-N |
SMILES | C1(=CCN(C)CC1)C1C=CC=CC=1.Cl |
CAS DataBase Reference | 23007-85-4 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H301-H370 |
Precautionary statements | P260-P264-P270-P301+P310-P405-P501 |
Hazard Codes | T |
Risk Statements | 25-39/23/24/25-36/37/38 |
Safety Statements | 45-39-26 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | UT8358950 |
HS Code | 2933.39.9200 |
HazardClass | 6.1(b) |
PackingGroup | III |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | M0896 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | 23007-85-4 | 100MG | ₹36859.13 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 5.06382 | MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem | 23007-85-4 | 10MG | ₹15290 | 2022-06-14 | Buy |
TCI Chemicals (India) | M2690 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride | 23007-85-4 | 25MG | ₹7200 | 2022-05-26 | Buy |
TCI Chemicals (India) | M2690 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride | 23007-85-4 | 100MG | ₹21200 | 2022-05-26 | Buy |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
Purification Methods
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]
References
[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |