Olopatadine hydrochloride
- CAS No.
- 140462-76-6
- Chemical Name:
- Olopatadine hydrochloride
- Synonyms
- OLOPATADINE HCL;Patanol;Olopatadin HCL;OLAPATADINE HCL;Olopatadine Hydrochlorde;Opatanol;AL-4943A;ALO4943A;OLOPATDINEHYDROCHLORIDE;Olatadine hydrochloride
- CBNumber:
- CB0144403
- Molecular Formula:
- C21H24ClNO3
- Molecular Weight:
- 373.88
- MOL File:
- 140462-76-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/21 14:26:55
| Melting point | 242-245?C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: ≥20mg/mL |
| form | solid |
| color | White to Light yellow |
| Merck | 14,6840 |
| BCS Class | 3(CLogP), 1 (LogP) |
| InChI | InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-; |
| InChIKey | HVRLZEKDTUEKQH-NOILCQHBSA-N |
| SMILES | C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl |
| CAS DataBase Reference | 140462-76-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310+P330 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-50 | |||||||||
| Safety Statements | 45-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HQ4135060 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Olopatadine hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O0391 | Olopatadine hydrochloride ≥98% (HPLC) | 140462-76-6 | 10MG | ₹8183.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O0391 | Olopatadine hydrochloride ≥98% (HPLC) | 140462-76-6 | 50MG | ₹34943.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0361 | Olopatadine Hydrochloride | 140462-76-6 | 1G | ₹19500 | 2022-05-26 | Buy |
Olopatadine hydrochloride Chemical Properties,Uses,Production
Description
Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.
Chemical Properties
White Solid
Uses
Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
Olopatadine hydrochloride Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| FDC Limited | +912226782653 | Mumbai, India | 30 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Precise Biopharma Pvt Ltd | +91-2267828600 +91-2267828600 | Maharashtra, India | 46 | 58 | Inquiry |
| Indoco Remedies Ltd | +91-2262871000 +91-2262871000 | Gujarat, India | 27 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Micro Orgo Chem | 58 |
| Flax Laboratories | 58 |
| USV Pvt Ltd | 58 |
| Apotex Pharmachem India Pvt Ltd | 58 |
| FDC Limited | 58 |
| Aarti Industries Limited (AIL) | 58 |
| Hetero Drugs Limited | 58 |
| Precise Biopharma Pvt Ltd | 58 |
| Indoco Remedies Ltd | 58 |
| Ralington Pharma | 58 |