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Theaflavin 3,3′-digallate

Theaflavin 3,3′-digallate Structure
CAS No.
30462-35-2
Chemical Name:
Theaflavin 3,3′-digallate
Synonyms
TFDG;theaflavin 3;Theaflawin3.;8-Gingerol Hplc;8-GINGEROL, HPLC 98%;Theaflavin 3,3’Theaflavin 3,3'-digallate;Theaflavin 3,3''-digallate;Theaflavin 3,3'-di-O-gallate;Theaflavin-3,3-digallate(TF3)
CBNumber:
CB0156596
Molecular Formula:
C43H32O20
Molecular Weight:
868.71
MOL File:
30462-35-2.mol
Modify Date:
2025/1/27 9:38:02
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Theaflavin 3,3′-digallate Properties

Melting point 226～230℃
Boiling point 1352.6±65.0 °C(Predicted)
Density 1.97±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, sealed storage, away from moisture and light
solubility DMSO : 41.67 mg/mL (47.97 mM; Need ultrasonic)
form Solid
pka 6.55±0.20(Predicted)
color Red-purple
InChIKey ZEASWHWETFMWCV-ISBUVJFSSA-N
CAS DataBase Reference 30462-35-2

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  29329990

Theaflavin 3,3′-digallate Chemical Properties,Uses,Production

Description

Theaflavin-3,3''-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 μM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.

Uses

Theaflavin 3,3''-Digallate has been found to be an inhibitor against human pancreatic α-Amylase.

Theaflavin 3,3′-digallate Preparation Products And Raw materials

Raw materials

Preparation Products

Theaflavin 3,3′-digallate Suppliers

Global( 163)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Chengdu Greenpure Biopharma CO.,Ltd 18283602253; +8618283602253 China 953 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
Chengdu GLP biotechnology Co Ltd 028-87075086 13350802083 CHINA 1824 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860; +8618080483897 China 3772 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10244 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23541 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Chengdu Greenpure Biopharma CO.,Ltd 58
career henan chemical co 58
Chengdu GLP biotechnology Co Ltd 58
Chengdu Biopurify Phytochemicals Ltd. 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Hubei Ipure Biology Co., Ltd 58
ANHUI WITOP BIOTECH CO., LTD 58
Dideu Industries Group Limited 58

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theaflavin 3 3,4,5-Trihydroxybenzoic acid (3,4,6-trihydroxy-5-oxo-5H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl] ester 8-GINGEROL, HPLC 98% 3,4,6-Trihydroxy-1,8-bis[[(2R)-3,4-dihydro-3α-(3,4,5-trihydroxybenzoyloxy)-5,7-dihydroxy-2H-1-benzopyran]-2α-yl]-5H-benzocycloheptene-5-one 3,4,6-Trihydroxy-1,8-bis[[(2R)-3,4-dihydro-5,7-dihydroxy-3α-(3,4,5-trihydroxybenzoyloxy)-2H-1-benzopyran]-2α-yl]-5H-benzocycloheptene-5-one 8-Gingerol Hplc [(2R,3R)-2-[1-[(2R,3R)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,5-trihydroxy-6-oxobenzo[7]annulen-8-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate Theaflavin-3,3-digallate(TF3) TFDG Theaflavin 3,3&rsquo Benzoic acid, 3,4,5-trihydroxy-, 1,1'-[(3,4,6-trihydroxy-5-oxo-5H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl]] ester Theaflavin 3,3'-digallate USP/EP/BP TheaflAVin-3-3’-digallateQ: What is TheaflAVin-3-3’-digallate Q: What is the CAS Number of TheaflAVin-3-3’-digallate Q: What is the storage condition of TheaflAVin-3-3’-digallate Q: What are the applications of TheaflAVin-3-3’-digallate [(2R,3R)-3-[1-[5,7-dihydroxy-2-(3,4,5-trihydroxybenzoyl)oxy-chroman-3-yl]-3,4,6-trihydroxy-5-oxo-benzo[7]annulen-8-yl]-5,7-dihydroxy-chroman-2-yl] 3,4,5-trihydroxybenzoate Theaflavin 3,3'-digallate Theaflavin 3,3'-di-O-gallate (2R,2'R,3R,3'R)-2,2'-(3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene-1,8-diyl)bis(5,7-dihydroxychroman-3,2-diyl) bis(3,4,5-trihydroxybenzoate) Theaflavin 3,3''-digallate Theaflavin 3,3''-digallate, 10 mM in DMSO Theaflawin3. 30462-35-2 C43H32O20 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract The group of Ginerols Miscellaneous Natural Products