6-Gingerol
- CAS No.
- 23513-14-6
- Chemical Name:
- 6-Gingerol
- Synonyms
- GINGEROL;Gingerols;rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one;6-GINGEROL;GINGEROL [6];(s)-3-decanon;6-Gingerol ,98%;6-Gingerol std.;[6]-Gingerol>(s)-(6)-gingerol
- CBNumber:
- CB4328683
- Molecular Formula:
- C17H26O4
- Molecular Weight:
- 294.39
- MOL File:
- 23513-14-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/25 20:17:06
| Melting point | 31℃ |
|---|---|
| Boiling point | 453.0±35.0 °C(Predicted) |
| Density | 1.083±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | methanol: soluble1mg/mL, clear, colorless |
| form | Pale yellow oil |
| pka | 10.02±0.20(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
| InChIKey | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
| SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC |
| LogP | 2.485 (est) |
| CAS DataBase Reference | 23513-14-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Gingerol(23513-14-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HE0757000 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
6-Gingerol price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G1046 | [6]-Gingerol ≥98% (HPLC) | 23513-14-6 | 5MG | ₹25741.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G1046 | [6]-Gingerol ≥98% (HPLC) | 23513-14-6 | 10MG | ₹47770.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50866 | [6]-Gingerol analytical standard | 23513-14-6 | 10MG | ₹45529.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 345868 | [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator P | 23513-14-6 | 5MG | ₹20510 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0413 | [6]-Gingerol | 23513-14-6 | 20MG | ₹33400 | 2022-05-26 | Buy |
6-Gingerol Chemical Properties,Uses,Production
Chemical Properties
Light yellow ceraceous solid
Uses
[6]-Gingerol has been used:
- to study its effects on transient receptor potential (TRP) channels
- to study its effects on experimental models of non-alcoholic steatohepatitis
- to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
- to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice
Definition
ChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
General Description
6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.
Biological Activity
6-Gingerol is the major pharmacologically-active component of ginger. It is known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. 6-Gingerol has been found to possess anticancer activities via its effect on a variety of biological pathways involved in apoptosis, cell cycle regulation, cytotoxic activity, and inhibition of angiogenesis.
Anticancer Research
6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, whichshowed antioxidant, anti-inflammation, and antitumor properties. It has the capacityto inhibit NOS, TNF-α, and COX-2 enzymes which are regulated by NF-κB(Aggarwal and Shishodia 2004; Wang et al. 2012). It hinders the cell growth ofprostate, gastric, and breast cancer cells and suppresses the lung metastasis ofB16F10 melanoma. It exhibits antitumorigenic effect in human colorectal cancercells via upregulating NSAID-activated gene-1 (NAG-1) (Aggarwal et al. 2008). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner (Singh et al. 2016b). ROS levels were significantlyincreased in K562 and MOLT4 cells treated with gingerol, and apoptosis wasinduced in leukemia cells by mitochondrial pathway (Wang et al. 2012).
6-Gingerol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Tashima Inc. | +91-802654 4588 | Bangalore, India | 19 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| India Glycols Limited | 91-120-3090100 | Uttar Pradesh, India | 8 | 58 | Inquiry |
| Natural Remedies Private Limited | 08069033749Ext 437 | Karnataka, India | 12 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Sami Labs Limited | 09886575758 | Karnataka, India | 26 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| AKASH PHARMA EXPORTS | 58 |
| Tashima Inc. | 58 |
| Pharma Affiliates | 58 |
| India Glycols Limited | 58 |
| Natural Remedies Private Limited | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Sami Labs Limited | 58 |
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