2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate
- CAS No.
- 1001067-09-9
- Chemical Name:
- 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate
- Synonyms
- Teoc-NT;2-(TRIMETHYLSILYL)ETHYL 3-NITRO-1,2,4-TRIAZOLE-1-CARBOXYLATE;3-Nitro-1-[2-(trimethylsilyl)ethoxycarbonyl]-1H-1,2,4-triazole;2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate;2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate;3-Nitro-1H-1,2,4-triazole-1-carboxylic Acid 2-(Trimethylsilyl)ethyl Ester;1H-1,2,4-Triazole-1-carboxylic acid, 3-nitro-, 2-(trimethylsilyl)ethyl ester;3-Nitro-1H-1,2,4-triazole-1-carboxylic Acid 2-(Trimethylsilyl)ethyl Ester 3-Nitro-1-[2-(trimethylsilyl)ethoxycarbonyl]-1H-1,2,4-triazole Teoc-NT
- CBNumber:
- CB01570298
- Molecular Formula:
- C8H14N4O4Si
- Molecular Weight:
- 258.31
- MOL File:
- 1001067-09-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:34
| solubility | Sol organics (CH2Cl2, THF, CH3CN, EtOAc); reacts with amines. |
|---|---|
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C8H14N4O4Si/c1-17(2,3)5-4-16-8(13)11-6-9-7(10-11)12(14)15/h6H,4-5H2,1-3H3 |
| InChIKey | BHTJYIDOVYPNKR-UHFFFAOYSA-N |
| SMILES | N1(C(OCC[Si](C)(C)C)=O)C=NC([N+]([O-])=O)=N1 |
| CAS DataBase Reference | 1001067-09-9 |
2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | T2544 | 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate | 1001067-09-9 | 1G | ₹8500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2544 | 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate | 1001067-09-9 | 5G | ₹34400 | 2022-05-26 | Buy |
2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate Chemical Properties,Uses,Production
Physical properties
Mp (dec.) 85–86 °C.
Uses
2-(Trimethylsilyl)ethoxycarbonyl (Teoc) group is one of the most useful protecting groups for amines, which can be cleaved by fluoride ion under neutral conditions. However, 2-(trimethylsilyl)ethyl chloroformate(Teoc-Cl), which is generally used for the introduction of the Teoc protecting group in amines, is quite unstable and easy to decompose; therefore, distillation is recommended at regular intervals. On the other hand, Teoc-NT is a highly stable, nonhygroscopic crystalline material and can be stored for long periods without decomposition. Generally, carbamate formation proceeds quickly under neutral conditions, and highly pure carbamates are obtained without tedious column chromatographic purification. Furthermore, the coproduct 3-nitro-1,2,4-triazole (NT) can be recycled. It participates in the reactions of Reactions with Amines and Aminoalcohols, Amine Protection for Nucleosides, Reaction with Alcohols, etc.
2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate Suppliers
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