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14,15-LEUKOTRIENE C4

14,15-LEUKOTRIENE C4 Structure
CAS No.
75290-60-7
Chemical Name:
14,15-LEUKOTRIENE C4
Synonyms
EXC4;EOXIN C4;14,15-LTC4;14,15-LEUKOTRIENE C4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
CBNumber:
CB0196624
Molecular Formula:
C30H47N3O9S
Molecular Weight:
625.77
MOL File:
75290-60-7.mol
Modify Date:
2023/5/21 10:59:17
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14,15-LEUKOTRIENE C4 Properties

storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
form Liquid.

14,15-LEUKOTRIENE C4 Chemical Properties,Uses,Production

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Uses

14,15-Leukotriene C4 is an acute inflammatory mediator.

14,15-LEUKOTRIENE C4 Preparation Products And Raw materials

Raw materials

Preparation Products

14,15-LEUKOTRIENE C4 Suppliers

Global( 26)Suppliers
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Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
BIOMOL INTERNATIONAL, LP (800) 942-0430 United States 1503 77 Inquiry
Biomol Feinchemikalien GmbH 49-40-8532600 Germany 479 74 Inquiry
Shanghai Yaoyun Biological Technology Co., Ltd. 400-002-6926 400-002-6926 CHINA 6852 58 Inquiry
Beijing Zhijie Fangyuan Technology Co., Ltd. 010-82897201 15810200961 CHINA 6984 58 Inquiry
Shanghai Jijin Chemical Technology Co., Ltd. 400-002-6926 15900443528 CHINA 6617 58 Inquiry
Boao Pike 010-57798038 15652371397 CHINA 6629 58 Inquiry
Resenbio 029-86354885 China 1777 50 Inquiry
Morning Student Science and Technology (Guangzhou) Co., Ltd. 020-36048871 13760856740 CHINA 6618 58 Inquiry
Shanghai Chaoyan Biotechnology Co., Ltd. 021-50840550 CHINA 6217 58 Inquiry
Supplier Advantage
Aladdin Scientific 58
BIOMOL INTERNATIONAL, LP 77
Biomol Feinchemikalien GmbH 74
Shanghai Yaoyun Biological Technology Co., Ltd. 58
Beijing Zhijie Fangyuan Technology Co., Ltd. 58
Shanghai Jijin Chemical Technology Co., Ltd. 58
Boao Pike 58
Resenbio 50
Morning Student Science and Technology (Guangzhou) Co., Ltd. 58
Shanghai Chaoyan Biotechnology Co., Ltd. 58

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14,15-LEUKOTRIENE C4 14,15-LTC4 EOXIN C4 EXC4 Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl- OBQVBASHEWLKCQ-PKBWNXTMSA-N 75290-60-7