ChemicalBook > Product Catalog >Pharmaceutical intermediates >1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

CAS No.: 287471-30-1

Chemical Name:: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

Synonyms: Terbinafine Impurity 45;Terbinafine Impurity 22;1-Chloro-6,6-dimethyl-2-hepten-4-yne;2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL;1-Chloro-6,6-dimethyl-2-hepten-4-ino;(E)-1-chloro-6,6-diMethylhept-2-en-4-yne;(2E)-1-chloro-6,6-dimethylhept-2-en-4-yne;1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE;2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-

CBNumber:: CB0198486

Molecular Formula:: C9H13Cl

Molecular Weight:: 156.65

MOL File:: 287471-30-1.mol

MSDS File:: SDS

Modify Date:: 2023/12/7 13:00:17

Request For Quotation

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Properties

Boiling point	207.5±23.0 °C(Predicted)
Density	0.946±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere, 2-8°C
InChI	InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3/b6-4+
InChIKey	ZIXABMZBMHDFEZ-GQCTYLIASA-N
SMILES	C(Cl)/C=C/C#CC(C)(C)C
CAS DataBase Reference	287471-30-1(CAS DataBase Reference)

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Chemical Properties,Uses,Production

Description

1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hepten-4-yne choose to inhibit COX-fungal squalene, so that reduction of membrane ergosterol, thus inhibiting the growth of fungi play an inhibitory role; right ergosterol synthesis of precursors and no inhibitory effect on other stages.

Uses

1-Chloro-6,6-dimethyl-2-heptene-4-yne is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.

Application

1-Chloro-6,6-dimethyl-2-hepten-4-yne is a chlorinating agent that has been used to minimise hydrochloric acid by converting it to chloride. It is also used in the chlorination of magnesium and other metals. 1-Chloro-6,6-dimethyl-2-hepten-4-yne has been shown to be an effective antifungal agent against dermatophytes such as Trichophyton rubrum and Microsporum canis. The compound is toxic to humans and animals because it produces acrolein and terbinafine during chlorination. It also produces hydrochloric acid as a by-product of chlorination.

Synthesis

1-Chloro-6,6-dimethyl-2-hepten-4-yne mainly due to keratin aggregation produce squalene, was squalene cyclooxygenase inhibition, squalene in the cells of a large number gathered in the form of lipid droplets penetrate fungal cell membrane, destruction of the membrane lipid composition, resulting in fungal death. A typical procedure for preparing of 1-chloro-6,6-dimethyl-2-hepten-4-yne using boron trichloride is as follows: Compound 1 (53 g, 0.38 mol) in 2800 mL of n-hexane was cooled to 10??15??. Boron trichloride (1 M in hexane, 480 mL, 0.48 mol) was added to the mixture at 15??20?? over a 10 min period. After 10 min of stirring at 20??, the mixture was quenched with 1000 mL of water and stirred for 10 min. The separated organic phase was washed with 20% NaCl, dried (MgSO4), and evaporated to afford the title compound 2 (57.1 g, 95%) in 9:1 E:Z ratio. Synthesis_287471-30-1

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Preparation Products And Raw materials

Raw materials

Preparation Products

Terbinafine Hydrochloride

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Suppliers

Global( 164)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	China	294	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	China	19805	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29858	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1319	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17365	58	Inquiry
CD Chemical Group Limited	+8615986615575	China	20342	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8615838112936	China	13194	58	Inquiry
changzhou huayang technology co., ltd	+8615250961469	China	9701	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
shandong perfect biotechnology co.ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
CD Chemical Group Limited	58
Henan Alfa Chemical Co., Ltd	58
changzhou huayang technology co., ltd	58

1-Chloro-6,6-dimethyl-2-hepten-4-yne: Uses; Preparation
1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hept....
Nov 1，2019

287471-30-1(1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE)Related Search:

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1-Methyl-aminomethyl naphthalene (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine 1-Chloro-6,6-dimethyl-2-heptene-4-yne (E)-N,6,6-triMethyl-N-(naphthalen-2-ylMethyl)hept-2-en-4-yn-1-aMine Terbinafine

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chlorempenthrin

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2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)- 1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE 1-Chloro-6,6-dimethyl-2-hepten-4-ino 2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL 1-Chloro-6,6-dimethyl-2-hepten-4-yne (E)-1-chloro-6,6-diMethylhept-2-en-4-yne (2E)-1-chloro-6,6-dimethylhept-2-en-4-yne Terbinafine Impurity 22 Terbinafine Impurity 45 287471-30-1 Chemical intermediate for Terbinafine