Dynasore
- CAS No.
- 304448-55-3
- Chemical Name:
- Dynasore
- Synonyms
- CS-1429;Dynasore;Dynasore, >=98%;Dynasore USP/EP/BP;Dynamin Inhibitor I;Dynasore monohydrate;Dynamin Inhibitor I, Dynasore;N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide;N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide;(E)-N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHOHYDRAZIDE
- CBNumber:
- CB02102104
- Molecular Formula:
- C18H14N2O4
- Molecular Weight:
- 322.31
- MOL File:
- 304448-55-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | >224°C (dec.) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml). |
| form | Off-white solid. |
| pka | 8.49±0.35(Predicted) |
| color | Beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 304448-55-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 22-24/25-61 |
| RIDADR | UN 3077 9/PG 3 |
| HS Code | 2928.00.2500 |
Dynasore price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 324410 | Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor i | 304448-55-3 | 10MG | ₹9490 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D5461 | Dynasore | 304448-55-3 | 10MG | ₹5500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D5461 | Dynasore | 304448-55-3 | 50MG | ₹11300 | 2022-05-26 | Buy |
Dynasore Chemical Properties,Uses,Production
Uses
Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.[Cayman Chemical]
Definition
ChEBI: A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity f dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Biological Activity
Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
Dynasore Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |