PP3
- CAS No.
- 5334-30-5
- Chemical Name:
- PP3
- Synonyms
- PP3;Amino d;NSC 1401;PP-3;PP 3;Inetetamab;PP3 ISO 9001：2015 REACH;PP3 - CAS 5334-30-5 - Calbiochem;4-AMINO-7-PHENYLPYRAZOL[3,4-D]PYRIMIDINE;4-AMINO-1-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1-PHENYLPYRAZOLE[3,4-D]PYRIMIDINE
- CBNumber:
- CB0230067
- Molecular Formula:
- C11H9N5
- Molecular Weight:
- 211.22
- MOL File:
- 5334-30-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 214-217 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMF, DMSO, Hot methanol |
| form | Off-white solid |
| color | Whit to Off-White |
| λmax | 240nm(H2O (pH 1))(lit.) |
| BRN | 198460 |
| CAS DataBase Reference | 5334-30-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 36/37/39-26 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29335995 | |||||||||
| NFPA 704 |
|
PP3 price More Price(2)
PP3 Chemical Properties,Uses,Production
Chemical Properties
Whit to Off-White Solid
Uses
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule inhibitors of this signaling pathway have been developed as a therapeuptic strategy to abate abnormal Src kinase activity. PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2 . At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.[Cayman Chemical]
Biological Activity
Negative control for the src kinase inhibitor PP 2 (3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ). Inhibits EGFR kinase (IC 50 = 2.7 μ M).
PP3 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Bicon Healthcare | 08066085815Ext 778 | Hyderabad, India | 1 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25196 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |