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WS 12

CAS No.: 68489-09-8

Chemical Name:: WS 12

Synonyms: WS 12;AR-15512;Cooler-12;Cooling agent WS12;Cooler than menthol;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide;N- (4- methoxy phenyl) - menthol -3- carboxylase;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12);(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide;Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)-

CBNumber:: CB02455758

Molecular Formula:: C18H27NO2

Molecular Weight:: 289.41

MOL File:: 68489-09-8.mol

MSDS File:: SDS

Modify Date:: 2024/11/15 19:19:13

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WS 12 Properties

Boiling point	447.8±28.0 °C(Predicted)
Density	1.029±0.06 g/cm3(Predicted)
vapor pressure	0-0Pa at 20-50℃
FEMA	4681 \| (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
storage temp.	-20°C
solubility	DMSO: >20mg/mL
pka	14.18±0.70(Predicted)
form	White to off-white powder.
color	white to off-white
Odor	at 100.00 %. cool minty
Odor Type	minty
JECFA Number	2079
InChIKey	HNSGVPAAXJJOPQ-XOKHGSTOSA-N
LogP	3.95 at 22℃ and pH7.7
CAS DataBase Reference	68489-09-8

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P391-P501
Hazard Codes	N
Risk Statements	50
Safety Statements	53-61
RIDADR	UN 3077 9 / PGIII

WS 12 price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	W0519	WS-12 ≥98% (HPLC), powder	68489-09-8	5MG	₹16064.3	2022-06-14	Buy

Product number	Packaging	Price	Buy
W0519	5MG	₹16064.3	Buy

WS 12 Chemical Properties,Uses,Production

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical Properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

Uses

WS 12 is a potent TRPM8 agonist.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

WS 12 Preparation Products And Raw materials

Raw materials

Preparation Products

WS 12 Suppliers

Global( 121)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	China	3882	58	Inquiry
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	China	3002	58	Inquiry
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	China	874	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	+8615858145714	China	9215	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29884	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39894	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32080	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23541	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58

WS 12 Spectrum

WS 12(68489-09-8)¹HNMR

68489-09-8(WS 12)Related Search:

(2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium sodium salt WSB1 (A-10) WSP-5 5,7-Dihydro-2-methylthieno[3,4-d]pyrimidine WS6

WS3 WS-383 Menthoxypropanediol Cooler 5(WS-5) 2-Isopropyl-N,2,3-trimethylbutyramide

WS 12

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WS 12 (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE Cooling agent WS12 (1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- N- (4- methoxy phenyl) - menthol -3- carboxylase N-(4-Methoxyphenyl)-p-menthane-3-carboxamide N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12) Cooler than menthol AR-15512 Cooler-12 HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide 68489-09-8