2-Isopropyl-N,2,3-trimethylbutyramide
- CAS No.
- 51115-67-4
- Chemical Name:
- 2-Isopropyl-N,2,3-trimethylbutyramide
- Synonyms
- WS-23;2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE;N,2,3-Trimethyl-2-propan-2-ylbutanamide;FEMA 3804;Trimethyl Isopropyl Butanamide;2-Isopropyl-N,2,3-trimethylbutanamide;N,2,3-Trimethyl-2-isopropylbutanamide,WS-23;3-trimethylbutyramide;methyldiisopropylpropionamide;N,2,3-TRIMETHYL-2-ISOPROPYLBUTANAMIDE
- CBNumber:
- CB4227036
- Molecular Formula:
- C10H21NO
- Molecular Weight:
- 171.28
- MOL File:
- 51115-67-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/21 13:10:12
| Melting point | 58-61 °C |
|---|---|
| Boiling point | bp0.35mm 83-85° |
| Density | 0.9419 (rough estimate) |
| vapor pressure | 0.3-0.32Pa at 25℃ |
| FEMA | 3804 | 2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE |
| refractive index | 1.4621 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 16.46±0.46(Predicted) |
| form | Solid |
| color | White to Almost white |
| Odor | at 25.00 % in dipropylene glycol. mild cooling mentholic minty |
| Odor Type | minty |
| JECFA Number | 1595 |
| Merck | 14,9716 |
| LogP | 2.5 at 25℃ and pH7 |
| CAS DataBase Reference | 51115-67-4(CAS DataBase Reference) |
| EPA Substance Registry System | Butanamide, N,2,3-trimethyl-2-(1-methylethyl)- (51115-67-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H302 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-52/53 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
2-Isopropyl-N,2,3-trimethylbutyramide price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | I0729 | 2-Isopropyl-N,2,3-trimethylbutyramide min. 98.0 % | 51115-67-4 | 5G | ₹2800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0729 | 2-Isopropyl-N,2,3-trimethylbutyramide min. 98.0 % | 51115-67-4 | 25G | ₹5300 | 2022-05-26 | Buy |
2-Isopropyl-N,2,3-trimethylbutyramide Chemical Properties,Uses,Production
Description
2-isopropyl-N,2,3-trimethylbutyramide is one nearly odorless white crystalline powder widely used as a coolant in medicinal preparations, oral care products, foodstuffs, cosmetics, and confection-eye products. It is an artificial synthesis cooling agent and could be synthesized by the Ritter reaction of 2,2-diisopropylpropionitrile (DIPPN) with methanol in the presence of acid. Compared with menthol, WS-23 is characterized by a continuous and long-lasting cooling and refreshing effect with no side effects of burning or stinging sensations. As an important additive in menthol cigarettes, WS-23 can cover up the bitter and astringent taste of cigarettes, make the cigarette feel fresh, improve the coordination and softness of cigarette smoke, and reduce the thorn in the mouth and throat. WS-23 is also compatible with other flavors and cooling agents[1].
Chemical Properties
N,2,3-Trimethyl-2-isopropylbutanamide is a white, crystalline powder,which gives a physiological
cooling sensation on skin or mucosa. It is mainly used to create cooling
and freshness in oral care preparations.
The material can be prepared by a Ritter reaction using N,2,3-trimethyl-2-
isopropylbutyronitrile as the starting material and alkylating agents such as, for
example, borates, carbonates, or phosphates.
Uses
Physiological coolant in foods, beverages, tobacco products, toiletries, cosmetics and pharmaceuticals.
Trade name
Winsense WS-23 (Renessenz).
References
[1] Ze-Hong Wu. “Acute and subacute inhalation toxicity assessment of WS-23 in Sprague-Dawley rats.” Journal of Applied Toxicology (2021): 1826–1838.
2-Isopropyl-N,2,3-trimethylbutyramide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Neoloba Speciality Pvt Ltd | +91-9967190452 +91-9833575748 | Maharashtra, India | 27 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Anshul Specialty Molecules Pvt. Ltd.(Anshul Life Sciences) | 91-22-26865566 | Maharashtra, India | 21 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 12312 | 58 | Inquiry |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | China | 2967 | 58 | Inquiry |
| COSMAN CHEMICAL CO., LTD. | +8613761622051 | China | 14 | 58 | Inquiry |
| Hebei Fengmu Trading Co., Ltd. | +8613393234347 | China | 2989 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |